1 
CONTENTS 
Page 
2 
Participants 
Public Interest Groups Notified 5 
Opening Remarks, Dr. Fredrickson, Chairman 6 
Safeguards for Recombinant DNA Research, Dr. Berg..... 11 
Development of NIH Policy, Dr. Stetten 27 
Proposed Guidelines: Summary & Review, Dr. Singer......... 34 
Viewpoints of the Drafting Committee, Drs. Hogness & Curtiss 60 
Committee Discussion 70 
Physical Containment, Dr. Barkley 77 
Committee Discussion 87 
Questions from Public 104 
Public Statements to Committee 107 
Adjournment, First Day 152 
Further Public Comments, Second Day 152 
Summary of Major Issues, Dr. Stetten 176 
Committee Discussion 180 
Adjournment, Second Day 208 
APPENDIXES 209 
A: Communication from Boston Area Recombinant DNA Group 
B: "The Detrick Experience as a Guide to the Probable 
Efficacy of P4 Microbiological Containment Facilities 
for Studies on Microbial Recombinant DNA Molecules," 
A.G. Wedum, Jan. 20, 1976 
[ 142 ] 
