60 
existing grants, the supporting agency can review the estimates of hazards, 
the proposed containment facilities and certification, and decide whether or 
not to endorse the proposal without peer review, unless there are unresolved 
questions concerning the proposal. 
That concludes the summary of the guidelines. 
DR. FREDRICKSON: Thank you very much, Maxine. That was a superb job. 
I think we will ask you to provide us with some glossies of those slides. 
There may be many who would be interested in having them. 
Your presentation by no means being the cause — I am sure that some 
members of the committee are getting a little restive at the didactic tone 
of the meeting. I would describe some modification that has already been 
made, and that is that we have drastically cut Dr. Barkley's presentation 
this afternoon, eliminated the movie, and substituted a few slides for it in 
order to be sure that there is ample time for discussion. 
We are not running badly, however, from our schedule, and I do want to 
go ahead then with the last two presentations scheduled for this morning. 
We have asked and put an unpleasant restraint on both Drs. Hogness and 
Curtiss in the amount of time that we were able to allot to them, and I hope 
they will be able to conform to that restraint. We are very eager to hear 
from each of them because they represent at least in the beginning, in our 
understanding, some differences in the point of view within the committee 
as the guidelines were developed. 
First we would like to ask Dr. David Hogness, who is a Professor of 
Biochemistry at Stanford, if he would give us, then, a summary of his early 
impressions about these guidelines and such differences as may have existed 
during that drafting. 
Dr. Hogness, may we count on you for just 10 minutes? 
DR. HOGNESS: Sure, just ring a bell. 
DR. FREDRICKSON: I probably shall. 
DR. HOGNESS: In commenting on the formulation of these guidelines, it 
might be useful by way of background to indicate that we have been construc- 
ting and cloning recombinant DNA molecules in my laboratory since 1973, and 
that on the other hand, I have been associated with most of the successive 
steps that resulted in the guidelines before you. 
In reviewing these steps I have been struck by certain trends that I 
view with some concern, and which I should like to emphasize here. 
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