90 
DR. BARKLEY: I can't give you an answer to that. I would think that 
most of the facilities constructed over the last two decades have incorpor- 
ated into them the principal means which would allow them to be — or the 
laboratories within those facilities — to be qualified as a P3 laboratory. 
MR. HUTT: Do you have any dollar figure on what it would take to up- 
grade a PI or P2 to a P3? 
DR. BARKLEY: We are probably talking in the neighborhood of $200 to 
$300 per square foot. 
MR. HUTT: But on P3 are you talking of there being 100 or 1,000 or 
10,000 of them, Dr. Berg? 
DR. BERG: I can just make the comment that almost anybody working with 
tumor viruses today has the equivalent of a P3 laboratory. Those are quite 
extensively located, one would say certainly in the hundreds. 
But since I did build a P3 facility — convert a Pi to a P3 — I can tell 
you it is not ... it costs, to convert a 400-square-foot space from a stan- 
dard open lab to one which qualifies, I believe, as a P3 facility, about 
$25,000, exclusive of any of the standard laboratory equipment, which would 
ordinarily be used. We had to supply this for this room so that we wouldn't 
use the departmental facilities. To make 600 square feet of space, it cost 
us altogether between $35,000 and $50,000 to convert that space into a high, 
P3 facility. 
MR. HUTT: Well, it is very difficult to evaluate how much of a re- 
striction P3 is over Pi and P2 without knowing how many laboratories there 
are that would meet that requirement. 
DR. PETERSDORF : Most large institutions have at least one, I would 
say, and often several. 
DR. MELNICK: I would say every medical school in the country must have 
at least one, if not more. 
MR. HUTT: So that would mean that if you were to have a high level of 
requirement of P3 and eliminate some of the lower level PI and P2 it would 
not be that big a restriction on research? 
DR. FREDRICKSON: Dr. Hogness? 
DR. HOGNESS: I think that if you are doing this kind of research day 
in and day out and you have one of these facilities at the University of 
Washington or something, that is not going to be anywhere near enough. This 
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