118 
DR. SINGER: Okay, so perhaps the first thing to do would be to look 
at those items in this list of experiments not to be performed, which in a 
sense are also listed as experiments not to be performed in the proposed 
guidelines as they came out of La Jolla. Then we will know what remains 
as a matter of differences. 
DR. FREDRICKSON: This document is not in your brown book. Some of 
you do not have it. 
DR. SINGER: The cover sheet on the whole package is dated the first 
of February 1976, and it is a memorandum from the Department of Micro- 
biology and Molecular Genetics, Harvard Medical School, addressed to the 
members of the advisory committee. I believe it was mailed to everybody. 
Well, in any case, I will try and go over it. Could someone turn on 
the slide projector, please, and put back in the slide (2, page 38) that 
shows the list of experiments as they are in the La Jolla document that 
are not to be initiated at present? 
Slide 2 
Experiments Not to be Initiated at Present 
1. Experiments involving DNA from classes 3, 4, and 5 (CDC) 
2. Deliberate formation of recombinants when genes for dangerous 
toxins are present. 
3. Deliberate formation of recombinants from plant pathogens if likely 
to increase virulence or host range. 
4. Widespread release into environment of any organism containing 
recombinant DNA, except when no reasonable doubt of safety. 
5. Transfer of drug resistance traits to new microorganisms, if 
transfer could compromise drug use in medicine or agriculture 
6. Large scale experiments if harmful products made. Exceptions 
possible with permission of Advisory Committee. 
The first one, which are experiments involving DNA from classes 3, 4, 
and 5 of the CDC classification is also listed in the document to which I 
am referring on page 3, so that is one in which the two agree. 
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