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animals that P4 physical containment and EK2 are required, or P3 and EK3. 
However, after purification by cloning and the demonstration that only a 
segment of the viral DNA that contains harmless genes is involved, then 
containment can be moved to P3 and EK2. So that the experiments are per- 
mitted, but under what could probably be characterized as the strictest con- 
tainment requirements for any experiments. 
The only other item on page 3, as I understand it, that is different is 
number 9, which says that any recombinant DNA molecule or strains carrying 
them mentioned in items 1 through 8 which have already been made should no 
longer be used, but rather be autoclaved, et cetera. 
The guidelines as such do not refer to the disposition of anything that 
has been made thus far but which would be interdicted under the experiments 
listed as not to be done in the La Jolla guidelines. 
Did I muddle that, Don? You look slightly confused. 
DR. FREDRICKSON: Slightly. 
DR. SINGER: Okay, I will say it again, then. The La Jolla guidelines 
do not contain a statement comparable to number 9 relative to those experi- 
ments which are on the list of experiments not to be done in the guidelines. 
However, the advisory committee discussed that problem at the meeting at 
La Jolla, and, as I recall, the decision that they made was that any in- 
vestigator who has such materials needs to bring them to the attention of 
the advisory committee, and the advisory committee, together with the in- 
vestigator would presumably decide on the proper course of action. 
MR. HUTT: Why wasn't that statement that you just made in the 
guidelines? 
DR. SINGER: I am not sure whether it was considered a procedural 
matter, as was, for example, the certification of EK2 host-vectors, so that 
it is not a formal part of the guidelines, but in a sense it is not really 
different because, as I understand it, the guidelines are basically the 
minutes of the meeting, and that statement occurs in another part of the 
minutes . 
MR. HUTT: It occurs in the minutes? 
DR. SINGER: It is in the minutes of the La Jolla meeting. 
MR. HUTT: They have no effect. 
DR. FREDRICKSON: I am sorry, Peter? 
MR. HUTT: The minutes have no effect on the guidelines, obviously. 
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