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members of the committee could in no way be totally aware of all the recom- 
binant DNAs that had ever been made, some of which might be ones that should 
be autoclaved and others which pose no hazard. Therefore, as I guess is 
within the charge of the committee, a motion was made that anybody wishing 
to continue to use recombinants that were constructed with conditions or 
host-vectors with less than what the guidelines now specify ought to cone 
before the committee and allow the committee to evaluate the situation, in 
which case the committee could say autoclave it all, or it appears from the 
information you know that you can continue to use those recombinant clones. 
This is why it was not written into the guidelines. 
MR. HUTT: Well, there is nothing to preclude that being a condition of 
future funding of research by that laboratory. 
DR. HOGNESS: Yes, right. 
DR. FREDRICKSON: Is there any further comment on this matter? 
Well, I think, Dr. Goldstein, if you had the tine this evening, you 
will be us tomorrow, and you care to go through the present La Jolla guide- 
lines, and indicate those areas where they still seen at variance with, 
those important areas, with what you have written here, then you would be 
performing a great service for all of us, so that we night clearly have on 
the record and understand where those differences lie, and we could take 
that up in the norning. 
DR. BERG: Let me ask that you include in that charge better descrip- 
tion of what the word "banned" means. Forever? And if so, is that to in- 
clude the fact that even if as we anticipate safe hosts and vectors will be 
on hand, is the work still to be banned forever? Because I think there is 
a question of what assurance we have that any host or vector system would 
ever come anywhere near close to matching what we already can produce or 
conceivably would produce without _E. coli . So the word "banned" I find 
very difficult to understand. How does the timeframe work? and also what 
the alternative is. 
DR. FREDRICKSON: Dr. Goldstein had previously requested to speak, and 
had agreed to wait until tomorrow, and we will, if we may, devote much of 
our presentation tomorrow or as much as we can to these questions. 
DR. GOLDSTEIN: I will deal with the guidelines. 
DR. FREDRICKSON: Very good. 
DR. GOLDSTEIN: I still would like to sort of - I had a couple of other 
issues that I wanted to speak about. 
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