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genetically constructed and shown to provide a high level of biological 
containment as demonstrated by data from suitable tests performed in the 
laboratory. " 
I think one could, as an independent scientist, in interpreting these 
data make his own judgment based upon his own laboratory results without 
being required to do the way this is presently written, through any ad- 
visory committee procedure whatever. Now, there may be additional require- 
ments that I did not see. 
DR. SINGER: I think there are a couple of places where more specific 
indications of the kinds of tests that should be done are given for systems 
using plasmid vectors. 
MR. HUTT: Where are you reading from? 
DR. SINGER: Okay, starting on the bottom of page 20, I guess. 
DR. FREDRICKSON: This is in the draft guidelines in your brown book. 
DR. SINGER: There is an indication of the kinds of tests that might 
be used with plasmids. 
DR. HOGNESS: It is on page 25. 
DR. FREDRICKSON: Dr. Hogness says it is on page 25. 
DR. SINGER: Well, I was coming to that, yes. 
Further on, the same kind of thing is given for the lambda system — 
that is, specified use of the lambda tests that might be prescribed — and 
then finally, at the top of page 25 is a more general statement no longer 
in italics. 
MR. HUTT: But the top of page 25 is not a requirement, it is merely 
an encouragement. "Should" means you don't have to, and "is encouraged to" 
means you don't have to, so that your procedure that you have laid out 
is not mandatory. It is one that is encouraged. 
DR. BERG: I am sorry, but was it not true at the end of the La Jolla 
meeting there was a motion made and approved by the committee that no EK2 
vector would be certified for use by anybody, or accepted until the com- 
mittee had certified it? 
MR. HUTT: I just don't see that in here. 
DR. FREDRICKSON: Would any of those who were here on the committee 
have any objection to those minutes entering themselves into the guidelines? 
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