133 
MR. HUTT: That would solve the problem. 
DR. FREDRICKSON: Dr. Hogness? 
DR. HOGNESS: You might say that in general the word "should" was used. 
DR. FREDRICKSON: You mean because you were advisory? And you waited 
for Bethesda to put the articles-of-war language? 
(Laughter. ) 
All right, then I think the sense of that is clarified. 
Now, Dr. Koshland? 
DR. WRIGHT: May I ask one question before we move on to another 
subject? 
DR. FREDRICKSON: Yes, you may. Although your time is up, you may. 
DR. WRIGHT: Pardon? 
DR. FREDRICKSON: You may. 
DR. WRIGHT: Thank you. 
I am a little confused, but does what you are saying mean that all the 
tests are to be done prior to all experimentation, or will some work start 
before the tests are complete? What I am concerned about, obviously, is 
that the exprimentation of E^_ coli should be rechecked, checked by others 
in the field before any experiments are carried out. I am not sure that 
is the case. 
DR. FREDRICKSON: Dr. Berg? 
DR. BERG: As I understand it, certification of EK2 vectors is neces- 
sary prior to its utilization in any experiment that calls for an EK2 
vector. 
DR. WRIGHT: Who will certify it? 
DR. BERG: The committee, the committee which was set up and drafted 
the guidelines must review the documentation claiming an EK2 vector, 
and must actively certify it, and no experiments that require an EK2 
vector can be done before that has been certified and released. 
DR. FREDRICKSON: Dr. Koshland? 
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