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read our arguments against peer review in this area in our extended state- 
ments, and measure this against what the La Jolla guidelines are suggesting. 
Thank you. 
DR. FREDRICKSON: Thank you. Dr. Silverstone. 
DR. MC CARTHY: May I interrupt just for a second, please? 
Additional copies of the Boston statement have just arrived, so we 
now have about 250 of them. 
DR FREDRICKSON: We have about 4 minutes for discussion and comments 
or questions for Dr. Silverstone. 
Mr. Hutt? 
MR. HUTT: Could I just ask what you would propose in lieu of guide- 
lines? What form of regulatory control are you proposing? 
DR. SILVERSTONE: Well, we aren't opposing the existence of guidelines. 
I wouldn't go along with Dr. Brown. 
MR. HUTT: Then in addition? 
DR. SILVERSTONE: In addition to guidelines, which I think would re- 
flect general scientific thinking and general evaluation, we would recom- 
mend both local institutional biohazard review committees that would have 
certain authority, that would be able to criticize without the fear of lost 
jobs, and we are suggesting that these be composed of more than just 
principal investigators. 
We also propose that there be an independent body in the grant review 
structure of NIH that would consider the question of safety from a public 
health standpoint. 
DR. FREDRICKSON: Yes, Dan? 
MR. SINGER: There is one way in which one might catalyze activity at 
host research institutions, and focus concern on the questions that have 
been raised so well, I think by Dr. Silverstone. Let me suggest that were 
there to be issued by NIH as part of the guidelines, or in supplement to 
the guidelines, a requirement that in addition to the host institution's 
certification of the availability of particular containment facilities, 
the host institution should also be required to certify the availability 
of compensation within that host institution for anyone injured in the 
course of the experimental procedure, I suspect that the ripple effect of 
that kind of certification requirement would tend, in a very drastic and 
quick way, to focus attention on precisely the kinds of issues that have 
been raised here. 
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