12 
1944 to 1950, inclusive 
Bldg. 524: Brucellosis - 5 cases; psittacosis - 1 case 
Bldg. 429: Brucellosis - 22 cases 
Bldg. 432: Brucellosis - 15 cases 
Bldg. 504: Tularemia - 9 cases in 1944-46 
Bldg. 525: Tularemia - 26 cases 
Other buildings and the pilot plant accounted for the remainder 
of the 147 infections. 
2. 1951 - 1959, inclusive, with 224 cases (99 were tularemia) 
In 1950, the first experimental ventilated protective Class I 
cabinet was tested and the first commercial stainless steel models were 
delivered by S. Blickman Company. The first cabinets were placed in buildings 
in which only brucella was under study, because of the severity of the disease 
and the absence of effective antibiotic treatment. The "tularemia buildings" 
were the last to receive protective cabinets, because use of a killed vaccine 
modified the severity of the disease and antibiotic treatment was effective. 
I 
By 1954, there were 11 buildings containing at least 87 of the new stainless 
steel ventilated cabinets, mostly of the size 60 inches wide; none were of the 
36 inch size. Another 7 buildings had 13 of these safety cabinets. 
It is difficult to select examples of P3 and P4 containment during 1951 
through 1959, because this was a period of transition from old to new buildings 
and realignment of research. Also, certain buildings must be excluded because 
their activities were remote from anything likely to be done in recombinant 
DNA research. The excluded buildings were those in which experimental aerosols 
were studied as such or by animal challenge, in large tanks or in the 1,000,000 
liter armor-plated sphere, and the pilot plants and associated laboratories 
engaged in large-scale production of microorganisms or toxin. 
Building 376, with Class I and Class III Cabinets . Nevertheless, 
Building 376, specializing in study of lesser-volume aerosols from liquid 
[383] 
