16 
"Of 15 persons engaged in laboratory purification studies of 
enterotoxin, one had conjunctivitis, one had a nondescript chemical 
irritation of the right eye, one had general skin reactions, one 
had a severe facial skin reaction, one had dermatitis, one had 
dermatitis and cold symptoms, one has observed no effects, and five 
were not reported on. No enteric reactions have been noted. 
" Workers using laboratory hoods did not experience these reactions . 
"One case was reported as having resulted from accidental inges- 
tion of material during a filter cleaning process. The operator 
wore all prescribed safety equipment including mask, gloves, etc. 
Accidental ingestion was considered to have occurred during a smoking 
period , which involved either violation of regulations or insufficient 
preparatory decontamination. 
" Conclusion : Oral pipetting, eating, smoking must be prohibited. 
"Twenty-three cases were reported during an operation in large, 
open areas where personnel wore surgical masks or face shields. Most 
of the cases involved conjunctivitis and acute pharyngitis, and two 
cases of diarrhea and vomiting occurred. It appeared that even the 
seemingly innocuous gesture of brushing some exposed body part against 
clothing worn during processing was sufficient to initiate sensitivity 
reactions. 
" Conclusion : Face shields and conventional surgical masks are not 
adequate. " 
4. Special Examples of Containment 
P3 . The best example at Fort Detrick, to demonstrate the probable 
effectiveness of a P3 system in recombinant DNA research that involves a 
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