Director, NIH 
2 
With a final draft of the guidelines and a preliminary draft of 
your decision paper accompanying them, you could then meet with 
Cooper and Mathews. In your review with them the initial focus 
should be on the issuance of the guidelines. The question then 
would be "where do we go from here?" This issue might be an 
appropriate subject for the Health Policy Board. Your decision 
and the guidelines need to be reviewed to determine how you will 
approach the issue of regulations because that will confront 
you immediately after issuance of the guidelines. That needs 
to be carefully reviewed with Mathews and Cooper since they are 
responsible for regulations. In this regard you have asked 
Dr. Jacobs to provide a policy memorandum outlining options for 
you with respect to a manual issuance. That memorandum might 
review options of the guidelines only, the guidelines plus an 
I & I Memo, or the guidelines and a manual issuance. 
4. The question of Government -wide adoption of the guidelines 
needs to be considered not only with Secretary Mathews but with 
Congress. As we discussed, I think it is necessary that you 
plan a briefing with staff on the Hill shortly before the 
guidelines are issued or certainly immediately thereafter. They 
need to be included much as we did the interagency representatives. 
Their views on the implementation of these guidelines Government- 
wide will need to be heard. 
5. Further down the line we need to meet with the foundations that 
might support this research and we also need to have you approach 
the journals who publish DNA recombinant research results. 
Perhaps a meeting for a select group of editors could kick that 
effort off much as the meeting youjield this past week. 
L# 
J6seph G. Perpich, M.D. , J.D. 
Enclosure 
cc: Dr. Stetten 
Dr. Jacobs 
Dr. Talbot 
[ 423 ] 
