Dr . Paul Berg 
- 2 - 
10 March 1976 
Considering the tested safety of baculoviruses for man 
and his environment and the potential benefit of further research on 
these viruses, I would like to suggest the reduction of containment 
requirements from + EK^ to P 2 + EK.£ . The P 2 + EK 2 containment 
is cautious in comparison to the shotgun experiments with invertebrate 
DNA ( P 2 + EK-^) which will surely involve introduction of viral genes 
harbored by the insects. I also wish to point out that agricultural 
research frequently does not have the funds to provide P 3 or P 4 
containment facilities. For my part, I will be working in the Department 
of Bacteriology and Biochemistry, The College of Agriculture, The 
University of Idaho, Moscow, Idaho 83843 beginning July 1976. Finding 
funds for P 3 or P^ containment will be difficult. Most of the research 
on these viruses are done at similar institutions. 
Can you provide help or advice in regard to the reduction 
of containment requirements for baculovirus research? I am most 
willing to document this case and write innumerable letters to appropriate 
people if necessary. I appreciate your attention to this matter. 
Sincerely, 
[ 500 ] 
