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of research in this country and abroad, we believe these guidelines 
will be adopted by other laboratories throughout the United States and 
that they will provide a basis for development of similar guidelines 
in foreign countries. 
If you have any questions or comments on the guidelines or the issues 
raised in my decision paper, I would be pleased to respond to them. 
Thank you very much. 
Sincerely yours, 
/s/ 
Enclosures 
DonaldS. Fredrickson, M.D. 
Director 
