PLEUROPNEUMONIA. 835 
and the natural disease) may exist in the same individual at 
the same time.” 
As to the protective effect of the operation, the Commission 
consider the point requires to be determined by further expe- 
riments. 
Professor Simonds, who was commissioned by the Royal 
Agricultural Society to visit Belgium to investigate the results 
of inoculation, reported in 1853, after numerous experi- 
ments — 
“That inoculation made by superficial punctures and 
simple erasions of the skin invariably fail to produce any 
local inflammatory action, being the reverse of the case with 
regard to the vaccine diseases, smallpox, and other specific 
affections, of which it is an indication of success. 
“ That the employment of fresh serous fluid and a clearly- 
made but small incision, during the continuance of a low 
temperature, will also almost always fail to produce even the 
slightest amount of inflammation. 
“ That deep punctures are followed by the ordinary phe- 
nomena only of such wounds when containing some slightly 
irritating agent. 
•“ That, with a high temperature, roughly-made incision, 
and serous fluid a few T days old, local ulceration and gangrene, 
producing occasionally the death of the patient, will follow 
inoculation. 
“That the sero-purulent matter taken from an inoculated 
sore causes more speedy action than the serum obtained from 
a diseased lung, and that removes cannot be effected on scien- 
tific principles. 
“ That oxen are not only susceptible to the action of a 
second, but of repeated inoculations with the serous exudation 
of a diseased lung. 
“ That an animal inoculated with the serous exudation is 
in no wav protected from the repeated action of the sero- 
purulent fluid which is produced in the wound as the result 
of the operation. 
“That animals not naturally the subjects of pleuropneu- 
monia, such as donkeys, dogs, &c., are susceptible to the 
local action both of the serous exudation from the lung and 
the sero-purulent matter obtained from the inoculated wounds. 
“ That inoculation made with medicinal irritating agents 
will be followed by similar phenomena to those observed in 
inoculation with the exuded serum. 
“ That inoculation often acts as a simple issue, and that 
the security, which at times the operation apparently affords, 
depends in part upon this, but principally on the unknown 
