HUMANE TREATMENT OF ANIMALS USED IN RESEARCH 5 
by the Commissioner. The Commissioner may refuse to approve a project 
plan for failure to comply with this Act and the policies enunciated herein. 
Sec. 10. The Commissioner shall upon application issue a letter of qualifica- 
tion to use animals in research to persons having all of the following qualifica- 
tions : 
(a) the applicant has been awarded a doctoral degree in medicine, veteri- 
nary medicine, physiology, psychology, or zoological science by an accredited 
university or college ; 
(b) the applicant has never been convicted of cruelty to animals or 
been found by the Commissioner to have participated knowingly in a viola- 
tion of this Act ; 
(c) the applicant is at the time of application employed or sponsored by 
a laboratory holding a certificate of compliance with this Act, or has 
applied for or received a grant of funds from an agency or instrumentality of 
the United States or 'from a person or agency acting pursuant to contract or 
authorization of the United States Government, for research involving use 
of animals, or is in the employ or service of an agency or instrumentality of 
the United States. 
Sec. 11. Letters of qualification authorized in section 10 shall be valid for no 
more than one year and may be limited to a shorter time and to specific projects 
by the Commissioner, but shall be renewed by the Commissioner if renewal is 
requested, subject to the requirements for an original letter of qualification. 
Sec. 12. Every laboratory holding a certificate of compliance, and every agency 
or instrumentality of the United States that uses animals in research, experi- 
ments, tests, training in scientific procedures or technique, or the production 
of materials, shall comply with the following requirements : 
(a) all projects shall be designed and executed so as to obtain maximum 
reduction and substitution ; 
(b) animals used in any way that would cause pain shall be anesthetized 
so as to prevent the animals from feeling pain during or after the experi- 
ment or procedure unless the project plan approved by the Commissioner 
states that anesthesia would frustrate the purpose of the project ; 
(c) no unanesthetized animal shall be burned, scalded, or subjected to 
perforation of the abdominal viscera, or to any similarly acutely painful 
procedure ; 
(d) regardless of the nature or purpose of any experiment or procedure, 
animals that would suffer prolonged pain or stress as a result of an 
experiment or procedure shall be painlessly killed immediately after the 
procedure causing pain or stress is completed, whether or not the objective 
of the experiment or procedure has been attained ; 
(e) animals used in surgery or other procedures causing pain or stress 
shall be given pain-relieving care and convalescence conditions substantially 
equal to those customarily or usually given to human patients before, 
during, and after similar procedures ; 
(f) anesthetics shall be administered only by a licensed veterinarian or 
a doctor of medicine qualified in anesthesiology, except that a student in a 
graduate medical school may do so for purposes of training when in the 
presence and under the immediate supervision of a licensed veterinarian 
or doctor of medicine ; 
(g) experiments or tests on animals shall be conducted only by persons 
holding letters of qualification under section 10 of this Act, or by students in 
a laboratory holding a certificate of compliance with this Act when in the 
presence and under the direct supervision of a person holding a letter of 
qualification under this Act, and all animals used by students in practice 
surgery or other painful procedures shall be under the complete anesthesia 
and shall be killed without being allowed to recover consciousness ; 
(h) all animals used shall be legally acquired and shall be kept only in 
conformance with the laws of the State in which the laboratory operates ; 
(i) all premises where animals are kept shall provide a comfortable rest- 
ing place, adequate space and facilities for exercise normal to the species, 
sanitary and comfortable cleanliness, and lighting, temperature, humidity, 
and ventilation appropriate to the species ; 
(j) animals shall receive food and water adequate to maintain - health 
and comfort and shall not be permitted to suffer pain or stress through ne- 
glect or mishandling ; 
