current developments in the field and discussed to what extent 
studies of the effects of drugs of abuse on lEGs are likely to provide new 
insights into the molecular underpinning of drug-seeking behavior. 
Among the topics discussed were the specificity of the activation of lEGs 
by drugs of abuse, the nature of the long-term alterations following the 
induction, and the possible relationship between the observed changes in 
I EG activity and behavior. Many of the questions discussed remain unresolved. 
Yet, there was excitement about the remarkable specificity in the patterns of 
IEG activation induced by different drugs in the CNS. The participants 
expressed confidence about the prospects of linking drug-induced IEG 
induction to specific alterations in peptide gene expression in identified 
populations of CNS neurons. 
This volume reflects the considerable optimism among drug abuse researchers 
that studies of lEGs offer a new path to identify the long-term effects of drug 
exposure in the CNS. The chapters reveal a sense of confidence that studies 
of the action of drugs of abuse on lEGs will greatly facilitate efforts to identify 
the neuronal systems critically involved in the development of drug addiction 
and the nature of the changes produced within these systems. 
AUTHORS 
Reinhard Grzanna, Ph.D. 
Senior Staff Fellow 
Roger M. Brown, Ph.D. 
Chief 
Neuroscience Research Branch 
National Institute on Drug Abuse 
Parklawn Building, Room 11A-33 
5600 Fishers Lane 
Rockville, MD 20857 
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