Contents 
Pape 
Introduction 1 
Reinhard Grzanna and Roger M. Brown 
Regulation of Immediate Early Gene Expression 3 
Brent H. Cochran 
Everything Activates C-fos— How Can It Matter? 25 
Steven E. Hyman , Barry E. Kosofsky, Tuong V. Nguyen, 
Bruce M. Cohen, and Michael J. Comb 
Immediate Early Genes: Their Involvement in Physiological 
and Pathological Responses in the Nervous System 39 
Michael D. Hayward, Tom Curran, and James I. Morgan 
Immediate Early Gene Activation and Long-Term Changes 
in Neural Function: A Possible Role in Addiction? 54 
Harold A. Robertson 
Acute Effects of Psychomotor Stimulant Drugs on Gene 
Expression in the Striatum 72 
Ann M. Graybiel 
Functional Organization of the Striatum: Relevance to Actions 
of Psychostimulant Drugs of Abuse 82 
Charles R. Gerfen 
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