AP-1 Binding (% control) 00 Fos mRNA (% control) 
A 
300 
200 
100 
0 
150 
100 
50 
FIGURE 6. 
■ Control 
E2 Acute 
13 Chr+Ac 
i 
Control 
Acute 
Chr+Ac 
Regulation of Fos mRNA and of AP-1 binding activity by acute 
and chronic cocaine in the rat NAc. Control rats received twice 
daily IP injections of saline for 14 days and an additional saline 
injection on day 15; as with the controls , acute rats received 
saline injections for 14 days but received a single injection of 
cocaine hydrochloride (15 mg/kg) on day 15; chr-rac rats received 
twice daily injections of cocaine for 14 days and an additional 
cocaine injection on day 15. Animals were sacrificed 45 minutes 
108 
