Henry, D.J., and White, F.J. Repeated cocaine administration causes 
persistent enhancement of D1 dopamine receptor sensitivity within the 
rat nucleus accumbens. J Pharmacol Exp Ther 258:882-890, 1 991 . 
Hoeck, W.; Rusconi, S.; and Groner, B. Down-regulation and phosphorylation 
of glucocorticoid receptors in cultured cells. J Biol Chem 264:1 4396-1 4402, 
1989. 
Hope, B.T.; Kosofsky, B.; Hyman, S.E.; and Nestler, E.J. Regulation of IEG 
expression and AP-1 binding by chronic cocaine in the rat nucleus 
accumbens. Proc Natl Acad Sci USA, in press. 
Hope, B.T., and Nestler, E.J. Effects of chronic cocaine on c-fos and other 
immediate early genes and on AP-1 binding in rat nucleus accumbens. 
Soc Neurosci Abstr 1 7:357, 1991. 
Kogan, J.H.; Nestler, E.J.; and Aghajanian, G.K. Elevated basal firing rates 
of locus coeruleus neurons in brain slices from opiate-dependent rats: 
Association with enhanced responses to 8-Br-cAMP. Eur J Pharmacol 
211:47-53, 1992. 
Koob, G.F., and Bloom, F.E. Cellular and molecular mechanisms of drug 
dependence. Science 242:71 5-723, 1988. 
Makman, M.H.; Dvorkin, B.; and Crain, S.M. Modulation of adenylate cyclase 
activity of mouse spinal cord-ganglion explants by opioids, serotonin and 
pertussis toxin. Brain Res 445:303-31 3, 1 988. 
Mitchell, P.J., and Tjian, R. Transcriptional regulation in mammalian cells by 
sequence-specific DNA binding proteins. Science 245:371 -378, 1989. 
Montminy, M.R.; Gonzalez, G.A.; and Yamamoto, K.K. Regulation of cAMP- 
inducible genes by CREB. Trends Neurosci 13:184-188, 1990. 
Morgan, J.I., and Curran, T. Stimulus-transcription coupling in the nervous 
system. Annu Rev Neurosci 1 4:421 -452, 1 991 . 
Nestler, E.J. Molecular mechanisms of drug addiction. J Neurosci 12:2439- 
2450, 1992. 
Nestler, E.J.; Erdos, J.J.; Terwilliger, R.; Duman, R.S.; and Tallman, J.F. 
Regulation of G-proteins by chronic morphine in the rat locus coeruleus. 
Brain Res 476:230-239, 1989. 
Nestler, E.J., and Tallman, J.F. Chronic morphine treatment increases cyclic 
AMP-dependent protein kinase activity in the rat locus coeruleus. Mol 
Pharmacol 33:1 27-1 32, 1988. 
Nestler, E.J.; Terwilliger, R.Z.; Walker, J.R.; Sevarino, K.A.; and Duman, R.S. 
Chronic cocaine treatment decreases levels of the G-protein subunits G la and 
G^ in discrete regions of rat brain. J Neurochem 55:1 079-1 082, 1 990. 
North, R.A.; Williams, J.T.; Suprenant, A.; and Christie, M.J. Mu and delta 
receptors belong to a family of receptors that are coupled to potassium 
channels. Proc Natl Acad Sci USA 84:5487-5491 , 1 987. 
Ptashne, M., and Gann, A.F. Activators and targets. Nature 346:329-331, 
1990. 
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