Number of IR Cells Number of IR Cells 
coc coc coc sat sal sal 
SCH-23390 (mg/kg) 
coc coc coc coc sal sal sal sal 
Sulpiride (mg/kg) 
FIGURE 9. Comparison of blockade of cocaine-induced Fos immunoreactivity 
produced by pretreatment with SCH-23390 or sulpiride. Neither 
antagonist alone had a marked effect on striatal c-fos staining. A 
dose-related decrease in the number of stained nuclei was seen 
with the D1 antagonist SCH-23390, whereas a clear dose-related 
decrease was not seen with the D2 antagonist sulpiride. 
(sal=saline, coc=cocaine) *p<0.05 
SOURCE: Young et al. 1991 
194 
