Appendix N. 
405 
b. Reprogramming of a somatic nucleus following nuclear 
transfer may result in (i) no activation of "embryonic" genes and 
early lethality, (ii) faulty activation of embryonic genes and an 
abnormal phenotype, or (iii) in faithful activation of “embryonic" eind 
“adult" genes and normal development of the clone. The latter 
outcome is the exception if it occurs at all. 
Fig IB 
Reprogramming in Nuclear Cloning 
Somatic Donof 
Nuclous 
1 
1 r ~~ ~ 1 
If I I 
1 
SsBmaismmiBa? 
• Must occur vory Shortty 
oftor nucloar trensfor 
• In vory dMoront contoxi; 
AO yao»o<ogoAoo<o 
I I 9 ■ 
» ■ -iii-n 
Normal 
Abnorm^t 
Fa/lad 
Development of Clones 
PRE -PUBLICATION VERSION 
