Appendix lll-C— Information on International Guidelines for Recombinant DNA • 325 
\lll. Countries in which the guidelines are applicable 
only to biological agents containing recombinant 
D\'A, or also cover the recombinant DNA mole- 
cules themselves: 
Country 
Onl\' to 
biological 
agents 
Also recombinant 
DNA molecules 
.Australia 
X 
Bulgaria 
X 
Canada 
(d 
P) 
Czechloslovakia . . 
X 
Cierman 
Democratic 
Republic 
X 
f'ederal Republic of 
Germany 
X 
Finland 
X 
France 
X 
Japan 
X 
Netherlands 
X 
New Zealand 
X 
Norway 
X 
South .Africa 
X 
Sweden 
X 
Switzerland 
X 
Taiwan 
X 
United Kingdom . . 
X 
United States .... 
Xb 
U.S.S.R 
X 
^Guidelines apply to all. but containment is not required for naked DNA. 
^ The Guidelines apply to recombinant DN.A e.'tperiments that are not ex- 
empt under Section l-E of the Guidelines. Recombinant DN.A molecules that 
are not in organisms or viruses are exempt from the Guidelines (I-E-1)." 
X/\'. Groups/Committees responsible for carrying out 
monitoring of containment procedures: 
Country Group 
Australia Institutional Biosafety Commit- 
tees. 
Bulgaria National Committee 
Canada "University and Medical Re- 
search Council Biohazards Com- 
mittees” 
Czechoslovakia . . . "Under consideration of the Na- 
tional Institutes of Public Health.” 
German 
Democratic 
Republic "Monitoring is carried out by 
local Biosafety Officers, wbo are 
representatives of the Committee 
in their institutions.” 
Federal Republic of 
Germany Officers for Biological Safety 
monitor the health of employees 
and compliance at laboratories; 
ZKBS (Zentrale Kommission fur 
die biologische Sicherheit) has 
overall responsibility. 
France "Local safety committees” 
Hungary "National Institutes of Public 
Health” 
Japan "Principal Investigator and Safety 
Officer” 
Netherlands "Site Inspection Commission” 
New Zealand "Local controlling Committees 
are charged with monitoring 
observance of Guidelines. 
Biological Safety Officers are ap- 
pointed to take immediate 
responsibility.” 
Norway "Physical containment: Norwe- 
gian National Institute of Public 
Health. Biological containment: 
Committee.” 
South Africa "Above P3, Biosafety Committee 
of Institute involved and 
SAGENE. Below P3, SAGENE 
only.” 
Sweden Not applicable. 
Switzerland "At the responsibility of either 
the individual investigator or a 
local biohazards committee.” 
Taiwan No response 
United Kingdom . . The Health and Safety Executive 
United States .... “Observance of containment is to 
be monitored by biohazards com- 
mittees located in institutions in 
which the research is conducted. 
Effectiveness of containment 
procedures is to be monitored by 
the principal investigator who is 
to report problems to tbe NIH.” 
U.S.S.R "Local biosafety commission, 
State Sanitary Inspection control 
group of Recombinant DNA Com- 
mission. 
