[ 537 ] 
mixtures into the paunch of calves, by means of a 
funnel, whofe end was covered with a piece of raw 
diftempered fldn, that the bead: might both fwallow 
and fuck in the difeafe. All thefe experiments could 
have no other effed than what followed ; which was, 
that the acrimony of the diftempered bile created 
firft a naufea, and then produced a violent fcouring, 
which killed the beaft, leaving marks of its irrita- 
tion on the inteftines. 
The pradice of inoculation is but lately followed, 
and even now but little known, in the provinces of 
France. Its advantages have not long fince been 
ftrangely difputed at Paris. In the cafe of inoculating 
cattle, inftead of a flip of raw hide taken from a 
beaft juft dead, or putting a puftule into the neck, 
they fhould either have paled in the dewlap cotton 
or filk dipped in well-digefted pus, or have inferted 
in proper incifions cotton-thread or filk foaked with 
pus. either on the fhoulders or buttocks ; the true way 
of inoculating in the Englifh manner. Some perfons 
have indeed thought, that to inoculate with the blood 
of the infeded would anfwer the intention ; but moft 
of the modern praditioners chufe to depend on di- 
gefted matter. 
Several conftitutions will not receive infedion, let 
them be inoculated ever fo judicioufly. A Ranby, 
a Hawkins, a Middleton, and other inoculators, will 
tell us, that the incifions have fometimes fuppurated 
fo much, and puftules have appeared round the edges 
of the wound, without any other particular marks of 
the difeafe j and yet the patient has never had the 
fmall-pox afterwards. The Marquis mentions art 
inftance fomewhat of the fame kind in his firft Me- 
moir, p. 147. 
Vol. 50. Zzz 
The 
