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XLIX. A remarkable Cafe of the Efficacy of 
the Bark in a Mortification . In a Letter 
to William Watfon, M. D. F.R. S. from 
Mr. Richard Grind all, Surgeon to the 
London Hof pit al . 
Auftin-Friars, Dec. 7th, 1757. 
S I R, 
Read Dec. 8, / g A H E following cafe being very fin- 
1 757 - gular has induced me to lay it 
before the Royal Society, and beg the favour to do 
it through your means. Although numerous inftan- 
ces are related in the records of medicine, of the great 
danger in interrupting nature in her operations, there 
is not one (fo far as I know), in which more violent 
and extraordinary effects have been produced, than 
in the following. 
It may happen alfo, that this inftance may be of 
fervice in afcertaining the virtue of the medicine in 
intermittents, when in the hands of men of judg- 
ment. 
On the 28th of June 17 f 7. Mary Alexander, aged 
31 years, of the parifh of Whitechapel, was brought 
into the London hofpital, having a mortification in 
both hands, which reached about an inch and half 
above the wrifts. All her toes, and about an inch of 
one foot beyond the laft joint, were mortified ; her 
nofe was alfo intirely deffroyed by a mortification j 
and all thefe happened at the fame time. Upon in- 
quiry into the caufe of this misfortune, I found, that 
on Monday the 30th of May fhe was feized with a 
quotidian 
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