[ 2 7 + ] 
the moft obftinate, and in certain cafes of the fluor 
albus. 
It muft be given with caution, beginning with a 
very fmail dofe, as one, two, or three grains, efpe- 
ciaily when it has been levigated again after its cal- 
cination : and thus it may be fafely given to children, 
and even to pregnant women. 
In giving it to robuft perfons, I always began by 
a fmail dofe, as 4 or y grains, which I gradually in- 
creafed to 18, according to the effects produced by 
lefs confiderable dofes. This medicine, which fome- 
times vomits or purges, fometimes all'o cures, efpe- 
cially in robuft conftitutions, without producing any 
vifible effedt. 
By gradually increafing the dofe of this medicine, 
I have given as far 24 as grains at a time, which had 
no other effedt, but to procure two or three mode- 
rate ftools the next day : but in this cafe it would be 
imprudent to continue its ufe without interruption ; 
becaufe, as it paftes ftowly, the dofe may polhbly 
unite with the ftrft at the time, that it begins to ope- 
rate ; and thefe two dofes thus joined might caufe a 
luperpurgation, which is always to be dreaded. 
I ftiould never have ventured to give this medicine 
to pregnant women, if chance had not convinced me, 
that it is not more dangerous for them than for 
others, when given with caution. For, among fe- 
veral women, whom I cured of bloody-fluxes with 
this medicine, there were fome, that were adtually 
with child, and did not know it themfelves, at the 
time of their taking it. They were all cured, and 
no accident happen’d to any of them. 
In 
