CONTENTS 
Page 
Testing Methods 150 
Designing a Test 150 
Use of Standardized Test Methods and Guidelines 152 
Pharmacokinetics 153 
Acute Toxicity Tests 153 
Skin and Eye Irritation/Corrosion Tests 154 
Repeated-Dose Toxicity Tests 154 
Carcinogenicity 155 
Developmental and Reproductive Toxicity 156 
Neurotoxicity 156 
Mutagenicity 157 
Current Trends 157 
The Role of Government in Testing 157 
Food and Drug Administration 158 
Environmental Protection Agency 161 
Consumer Product Safety Commission 164 
Department of Labor 164 
Department of Transportation 164 
Department of Agriculture 165 
Centers for Disease Control 165 
Federal Trade Commission 165 
State Uses of Animal Testing Data 165 
Pesticide Registrations 165 
Identification, and Classification of Toxic Substances 166 
Product Liability Considerations 167 
The Manufacturer’s Duty to Produce a Safe Product 167 
Methods of Testing Required 168 
Summary and Conclusions 168 
Chapter 7 References 169 
Table 
Table No. Page 
7-1. Number of Animals Needed to Detect Carcinogenicity in 90 Percent of 
All Tests for a Statistical Significance of 0.05 156 
