Ch. 8— Alternative to Animal Use in Testing • 193 
and L.F. Chasseand (eds.) (New York: John Wiley 
& Sons, 1977). 
40. Fund for the Replacement of Animals in Medical 
Experiments, "Report of the FRAME Toxicity Com- 
mittee, "Animals and Alternatives in Toxicity Test- 
ing, M. Balls, R.J. Riddell, and A.N. Worden (eds.) 
(New York: Academic Press, 1983). 
41. Goldberg, A.M., "Mechanisms of Neurotoxicity as 
Studied in Tissue Culture Systems,” Toxicology 
17:201-208, 1980. 
42 . Goldberg, A .M ., Director, The Johns Hopkins Cen- 
ter for Alternatives to Animal Testing, Baltimore, 
MD, personal communication, 1985. 
43. Griffith, J.F., Nixon, G.A., Bruce, R.D., et al., "Dose- 
Response Studies With Chemical Irritants in the 
Albino Rabbit Eye as a Basis for Selecting Optimum 
Testing Conditions for Predicting Hazard to the 
Human Eye,” Toxicol. Appl. Pharmacol. 55:501-13, 
1980. 
44. Grisham, J.W., “Use of Hepatic Cell Cultures to De- 
tect and Evaluate the Mechanisms of Action of 
Toxic Chemicals, ”Int. Rev. Exp. Pathol. 20:123-210, 
1979. 
45. Guy, R.H., and Fleming, R., "Transport Across a 
Phospholipid Barrier,” J. Colloid Interface Sci. 
83:130-137, 1981. 
46. Hassid, A., and Levine, L., "Induction of Fatty Acid 
Cyclooxygenase Activity in Canine Kidney Cells 
(MDCK) by Benzo(a) Pyrene,” J. Biol. Chem. 252: 
6591-6593, 1977. 
47. Healey, G.F., "Statistical Contributions to Experi- 
mental Design,” Animals and Alternatives in Tox- 
icity Testing, M. Balls, R.J. Riddell, and A.N. Wor- 
den (eds.) (New York: Academic Press, 1983). 
48. Hertzfeld, H.R., and Myers, T.D., “Alternatives to 
Animal Use in Testing and Experimentation: Eco- 
nomic and Policy Considerations,” contract report 
prepared for the Office of Technology Assessment, 
U.S. Congress, January 1985. 
49. Hill, J., Cautions Against the Immoderate Use of 
Snuff (London: Baldwin and Jackson, 1761). 
50. Huot, R., Fodart, J., Nardone, R., et ah, "Differen- 
tial Modulation of Human Chorionic Gonadotropin 
Secretion by Epidermal Growth Factor in Normal 
and Malignant Placental Cultures,” J. Clin. Endo- 
crinol. Metah. 53:1059-1063, 1981. 
51. Johnson, A.W., “Use of Small Dosage and Corneal 
Anaesthetic for Eye Testing In Vivo,” Proceedings 
of the CTFA Ocular Safety Testing Workshop: In 
Vivo and In Vitro Approaches (Washington, DC: 
Cosmetic, Toiletry, and Fragrance Association, 
1980). 
52. Johnson, H.J., Northup, S.J., Seagraves, P.A., et ah, 
"Biocompatibility Test Procedures for Polymer 
Evaluation In Vitro: I. Comparative Test System 
Sensitivity,” J. Biomed. Mater. Res. 17:571-586, 
1983. 
53. Johnson, H.J., Northup, S.J., Seagraves, P.A., et ah, 
"Biocompatibility Test Procedures for Materials 
Evaluation In Vitro: II. Quantitative Methods of 
Toxicity Assessment,” J. Biomed. Mater. Res. 
19:489-508, 1985. 
54. Kaufmann, J.J., Koski, W.S., Hariharan, P.C., et 
ah, "Theoretical and Quantum Prediction of Toxic 
Effects,” Drug Metah. Rev. 15:527-556, 1984. 
55. King, L.A., and Moffatt, A.C., "Hypnotics and Seda- 
tives: An Index of Fatal Toxicity,” Lancet 11:387- 
78, 1981. 
56. Kligman, A.M., "Assessment of Mild Irritants, "Prin- 
ciples of Cosmetics for the Dermatologist, P . Frost 
and S.N. Horwitz (eds.) (St Louis, MO: C.V. Mosby, 
1982). 
57. Knowles, B.B., Howe, C.C., and Aden, D.P., "Hu- 
man Hepatocellular Carcinoma Cell Lines Secrete 
the Major Plasma Proteins and Hepatitis B Surface 
Antigen,” Science 209:97-99, 1980. 
58. Lave, L., Omenn, G., Hefferman, K., et ah, "Model 
for Selecting Short Term Test of Carcinogenicity,” 
J. Am. Coll. Toxicol. 2:125-130, 1983. 
59. Leighton, J., Nassauer, J., and Tchao, R., "The Chick 
Embryo in Toxicology: An Alternative to the Rab- 
bit Eye,” Food Chem. Toxicol. 23:293-298, 1985. 
60. Leighton, J., Nassauer, J., Tchao, R., et ah, "Devel- 
opment of a Procedure Using the Chick Egg as an 
Alternative to the Draize Rabbit Test,” Product 
Safety Evaluation, A.M. Goldberg (ed.) (New York: 
Mary Ann Liebert, Inc., 1983). 
61. Lorke, D., "How Can We Save Animals in Toxicity 
Testing,” Progress Without Pain (Lord Dowding 
Fund, National Anti-Vivisectionist Society, Ltd., 
London) 22: 1984. 
62. MacMahon, B., and Pugh, T .F., Epidemiology : Prin- 
ciples and Methods (Boston, MA: Little, Brown &. 
Co., 1970). 
63. Marks, R., “Testing for Cutaneous Toxicity,” Ani- 
mals and Alternatives in Toxicity Testing, M. Balls, 
R.J. Riddell, and A.N. Worden (eds.) (New York: 
Academic Press, 1983). 
64. Martin , Y .C., Quantitative Drug Design: A Critical 
Introduction (New York: Marcel Dekker, Inc., 
1978). 
65. Maurice, D., "Pain and Acute Toxicity Testing in 
the Eye,” Alternatives to the Draize Eye Test, A. 
Goldberg (ed.) (New York: Mary Ann Liebert, Inc., 
1985). 
66. McCann, J., Choi, E., Yamasaki, E., et ah, "Detec- 
tion of Carcinogens as Mutagens in the Salmonella/ 
Microsome Tests: Assay of 300 Chemicals,” Proc. 
Natl. Acad. Sci. USA 72:5135-5139, 1975. 
67. McCulley, J.P., "Chairman's Summary," Alterna- 
