400 • Alternatives to Animal Use in Research, Testing, and Education 
and, as necessary, withdraw approval of As- 
surances; 
2. distribute to executive secretaries of initial re- 
view and technical evaluation groups, and to PHS 
awarding units, lists of institutions that have an 
approved Assurance; 
3. advise awarding units and awardee institutions 
concerning the implementation of this policy; 
4. evaluate allegations of noncompliance with this 
policy; 
5. have the authority to review and approve or dis- 
approve waivers to this policy (see V.D.); and 
6. conduct site visits to selected institutions. 
B. Responsibilities of PHS Awarding Units 
PHS awarding units may not make an award for 
an activity involving animals unless the institution 
submitting the application or proposal is on the list 
of institutions that have an approved Assurance on 
file with OPRR, and the institution has provided 
verification of approval by the IACUC of those sec- 
tions of the application or proposal related to the 
care and use of animals in PHS-supported activi- 
ties. If an institution is not listed, the awarding unit 
will ask OPRR to negotiate an Assurance with the 
institution before an award is made. No award shall 
be made until the Assurance has been submitted 
by the institution, approved by OPRR, and the in- 
stitution has provided verification of approval by 
the IACUC of those sections of the application or 
proposal related to the care and use of animals in 
PHS-supported activities. 
C. Conduct of Special Reviews/Site Visits 
Each awardee institution is subject to review at 
anytime by PHS staff and advisors, which may in- 
clude a site visit, in order to assess the adequacy 
of the institution’s compliance with this policy. 
D. Waiver 
Institutions may request a waiver of a provision 
or provisions of this policy by submitting a request 
to OPRR. No waiver will be granted unless suffi- 
cient justification is provided and the waiver is ap- 
proved in writing by OPRR. 
