Index • 435 
Cornell University, 213, 264, 269 
Cosmetic, Toiletry, and Fragrance Association 
(CTFA), 13, 266, 268 
Council of International Organizations of Medical 
Science (CIOMS), 295, 416-417 
CPSC 
animal use by, 9, 46 
regulations in, 157-158, 164, 390-391 
and research funding, 23 
Culpability, 306, 308, 313 
Dalhousie University, 360 
Data accumulation, 151, 223-228 
animal use and, 5, 8, 49-65, 180-181, 188-189 
epidemiologic, 155, 187 
by Federal agencies, 43-49, 161-163, 165, 166 
patent claims and, 247-248 
as a policy issue, 29-31, 43 
species choice and, 98 
by States, 165-166 
Data analysis, 152, 222 
of Ames tests, 187 
animal use and, 52-65 
of computer simulations, 138 
economy of animal use and, 245-246 
GLPs and, 293 
reduction in animal use by, 126-128, 175, 177, 
181 
Databases, 11-12, 219-228 
computer simulation and, 125-126 
EPA use of, 163-164 
epidemiologic, 124 
and information sharing, 224-238 
and micro-organism tests, 186 
reduction of animal use and, 176, 181 
Data sharing, 10, 11-12, 23-26, 220, 221-228 
by APHIS, 295-297 
computer systems and, 228-238 
by FDA, 295-297 
LADB and, 233-238 
by NIH, 295-297 
on-line, 229, 231-238 
proprietary interests and, 176, 252-253 
Delaware, 288, 307, 319 
Denmark, 18, 359, 363-366 
Department of Health, Education, and Welfare, 
U.S. (DHEW), 277, 279 
Department of Health and Human Services, U.S. 
(DHHS), 14, 33, 269, 295 
animal use by, 45, 49 
animal use guidelines of, 339 
animal use regulation by, 388-390 
databases and, 163-164 
funding by, 157, 264-265 
LADB and, 235 
Descartes, Rene, 74-75 
District of Columbia, 15, 276, 288, 290, 307, 316, 
319, 336 
DNA technology, 91, 121, 123, 125, 185-186, 188, 
261 
DOD 
and animal use, 15, 44-45, 49 
animal use regulations in, 16, 26, 158, 386-388 
Dodge Foundation, Geraldine R., 13, 264, 269 
DOE, 45/162, 388 
DOT 
animal use by, 9, 45 
animal use regulation and, 158, 164, 297, 386 
Dow-Corning, 131 
Draize eye irritancy test, 8 
alternatives to, 183-184, 259, 266 
CPSC modification of, 391 
funding for alternatives to, 13, 268 
methodology of, 154 
and policy options, 21 
restrictions on, 27-28 
trends in use of, 157 
Drug Enforcement Agency, U.S., 324 
Duke University, 125 
Economics 
alternatives to animal use and, 13, 189 
of animal use, 12, 13, 89, 115, 116, 123, 128, 
151, 181, 206, 209, 243-253, 265-266 
of the Animal Welfare Act, 278, 279, 281, 287 
data sources and, 220, 221, 223 
of GLPs, 294 
of IACUCs, 342 
of LADB, 235 
pound release laws and, 319 
proprietary interests and, 252-253 
regulations and, 251 
of research, 245-248, 250-251 
and species choice, 99 
of testing, 155, 157, 184, 248-251, 252-253 
Education 
alternatives to animal use in, 10-11, 208-214 
animal use in, 30, 199-214 
animal use regulation in, 321-322 
computer simulations in, 211-214 
funding of, 268-269 
overlap with research, 202 
Environmental Protection Agency. See EPA 
EPA 
animal use by, 9, 46 
and data accumulation, 163-164, 221, 229 
funding for toxicological research by, 23, 265 
GLPs and, 292-294 
and the LD S0 test, 19 
literature prepared for, 219 
