436 • Alternatives to Animal Use in Research, Testing, and Education 
protocol restriction and, 28 
and regulation of animal use, 13, 15, 157, 
161-164 
and testing economics, 251 
testing guidelines and, 152, 248, 384-385 
Epidemiology 
database use in, 124 
protocol as alternative to animal use, 163, 181 
Ethics 
of animal use, 6, 71-82, 200, 202 
and economics, 247 
of embryo use in research, 133 
of invertebrate use, 134 
Ethics and Values in Science and Technology 
(EVIST), 262 
FAA, 277 
FDA, 292-295 
animal use by, 9, 45 * 
animal use regulation in, 386, 388-389 
baldness prevention and, 92 
CPSC contracts with, 390 
and data collection, 31, 47-49 
and data sharing, 176, 295-297 
economics of, 251 
funding by, 13, 23, 264-265 
GLPs and, 292-293 
guidelines for, 337, 383 
hepatitis B vaccine and, 91 
and the LD S0 test, 19 
literature prepared for, 219 
product liability testing requirements by, 167 
protocol restriction and, 28 
regulation of animal use by, 13, 14 
regulatory activities by, 157, 158-160, 165 
testing guidelines and, 152, 383 
and toxicological testing, 150-151 
Federation of American Societies for Experimental 
Biology (FASEB), 235-236, 238, 346, 348 
Florida, 286, 288 
anticruelty laws in, 307, 308, 314 
pesticide program in, 166 
pound release laws in, 319, 320 
regulation of animal use in, 321-322 
RRFs in, 287 
FOIA 
and data sharing, 24-25, 223 
GLPs and, 293 
regulation of animal use and, 297 
unpublished information and, 221-222 
USDA and, 290 
Food and Drug Administration, U.S. See FDA 
FRAME, 153-154, 189-190, 267 
France, 220 
Francis, Saint, 74 
Friends of Animals, Inc. v. U.S. Surgical Corpora- 
tion, 315, 316, 323-328 
Freedom of Information Act. See FOIA 
FTC, 9, 158, 165 
Fund for Replacement of Animals in Medical Ex- 
periments. See FRAME 
GAO 
APHIS and, 286 
military research and, 293 
USDA and, 289-290 
Genetics. See DNA technology; RNA replication 
Georgia, 288, 307, 308, 319 
Germany, Federal Republic of, 359, 366-367 
Good Laboratory Practices (GLPs), 292-294 
Guide for the Care and Use of Laboratory Animals 
(NIH). See NIH, guidelines by 
Guidelines, for animal use, 13, 14, 16, 31, 33, 152, 
157-167, 176, 200-202, 291, 293-296, 335-352, 
361, 383-393, 395-400, 412-417 
Harrison, R.G., 120 
Harvard University, 115 
Hatch, Orrin G., 3 
Hawaii, 288, 307, 309, 318, 319 
Health Professions Education Assistance Amend- 
ments of 1985, 13, 269, 291 
Health Research Extension Act of 1985, 14, 281, 
291-292 
Humane treatment, principle of, 6, 78-79 
Hume, David, 74-75 
IACUC, 15, 337-344 
Idaho, 288, 307, 309, 319 
ILAR, 5 
and data collection, 31, 50, 53-55, 56, 57, 58-59, 
202-203 
and LADB, 233-234, 236 
NSF funding of, 262 
Illinois, 288, 307, 319 
regulations in, 314, 316-317, 321 
RRFs in, 287 
Illinois, University of, 267 
India, 56 
Indiana, 288, 307, 308, 319 
Industry 
data sharing and, 219, 221-222 
economics and, 252-253 
research funding by, 13, 22 
Information centers, 220 
Information, unpublished, 219-220, 221-222, 
224-228 
Insects, 186-187 
