Volume II - Section I - Introduction 
Page II - 1 
1. INTRODUCTION 
This volume contains a database of the results of the computational fluid dynamics (CFD) 
simulations for the research done on the National Institutes of Health Ventilation Design 
Handbook on Animal Research Facilities using Static Microisolators. 
Section 1 contains an overview of the basic room configuration studied and the variations 
considered. It is impossible to present all the data generated by the CFD simulations. The 
analysis of all the results produces an enormous quantity of data that would be difficult to present 
and interpret in its entirety. This volume contains summaries of the data in several forms. 
Section 2 contains histograms of mean values for each room considered, as they apply to both 
the scientists’ breathing zone and the cages, for temperature, relative humidity, and CO2 and NH3 
concentrations. 
Section 3 contains rankings of the rooms based on different variables, for example, the selection 
of the room configuration with the lowest NH3 concentrations in the cages. 
Section 4 contains a two page summary of each room simulation, including a description of the 
room, mean values and standard deviations for all parameters, and histograms showing the 
distribution of values in the cages. 
1.1 Outline of CFD Baseline Model 
A typical animal research facility of average size, air change rate, rack layout, mouse population, 
pressurization, and so on, was modeled as the baseline model for the CFD simulations. The 
general features of the room are shown in figure 1.01 and are listed below. 
