CONTENTS 
PREFACE 1 
BACKGROUND 9 
Terre Haute Prison Experiments, 1943-1944 13 
Implementing the Experiments 20 
Developments in the Science and Prevention of Sexually Transmitted Diseases ... 23 
GUATEMALA EXPERIMENTS 1946-1948 27 
Initial Experiment Design 28 
Treatment Programs and Goodwill Efforts 32 
Serological Experiments 36 
Penitentiary 37 
Children 38 
Leprosarium 40 
Psychiatric Hospital 41 
Intentional Exposure Experiments 41 
Overview 41 
Gonorrhea Experiments 43 
Syphilis Experiments 52 
Chancroid Experiments 69 
Winding Down the Guatemala Experiments 70 
Extension of the Grant 70 
Disposition of the Laboratory 71 
Race and Secrecy during the Guatemala Experiments 72 
Issues of Race 72 
Concerns about Secrecy 74 
THE POST-CUTLER CONTINUATION OF THE GUATEMALA 
EXPERIMENTS AND FINAL REPORTS 1948-1955 81 
Serology Experiments 82 
Continuing Observations 83 
PUBLICATION OF THE GUATEMALA DATA 85 
AFTERWORD 87 
REVIEWING ETHICAL STANDARDS IN CONTEXT 91 
Current Human Research Protections and Ethical Requirements of Our Own 
Time 92 
Longstanding Ethical Principles 93 
Contemporaneous Standards for Ethical Research in 1946-1948 97 
Evaluating General Mitigating Arguments 101 
Evaluating Historically Specific Mitigating Arguments 104 
in 
