19 , 6 
Lantin: Methods of Serum Application 
641 
under certain conditions. The combined method (serum per 
rectum and intramuscular injection) has given just as good 
results as any method of administering the serum, and is safer 
than the intravenous method. 
Finally, the serum acts in a specific manner, but at the same 
time it may act as a foreign protein, producing nonspecific an- 
tibodies. Above all it must be given early, even in cases where 
bacillary dysentery is only suspected, in order to produce good 
results. 
ACKNOWLEDGMENTS 
To Prof. Ariston Bautista, chief of the department of medi- 
cine, University of the Philippines, I acknowledge sincerely my 
high obligations for placing at my disposal all the material 
available in the department; also to Dr. Otto Schobl and Dr. 
C. S. Panganiban, of the Bureau of Science, who prepared the 
serum and made the bacteriological examinations of the stools 
for me. 
REFERENCES 
1. Bahr, P. H. Manson Brit. Med. Journ. 1 (1914) 249-296. 
2. Cowan, J. M., and Miller, H. Journ. Roy. Army Med. Corps 31 (1918) 
228. 
3. Doerr, R. In Kraus und Levaditi, Handbuch der Technik und Methodik 
der Immunitats-Forschung. Gustav Fisher, Jena (1909) 2, 164. 
4. Fisher, J. B. Brit. Med. Journ. (January 13, 1917) 43. 
5. Lantin, P. T. Philip. Journ. Sci. § B 13 (1918) 261-268. 
6. Idem. Philip. Journ. Sci. 14 (1919) 19-50. 
7. Miller, J. L. Journ. Am. Med. Assoc. 66 (1916) 1765. 
8. Musgrave, W. E., and Sison, A. G. Philip. Journ. Sci. § B 9 (1914) 
241-251. 
9. Shiga, K. Modern Medicine, by Osier, W., and McCrae, T., ed. 2, Phila- 
delphia and New York, Lea and Febiger 1 (1913) 766-782. 
