24 
The Philippine Journal of Science 
1919 
Method of treatment . — The view that sensitized typhoid vac- 
cine is considered less toxic than nonsensitized typhoid vaccine 
seems to be the consensus among investigators at present. 
Cecil, (2) Garbat, (8) and Nichols (35) have shown by experiments 
with animals that such is the case. Cecil, however, has found 
that the lethal dose of sensitized typhoid vaccine is three times 
as large as that of the nonsensitized bacilli. Reasoning from 
this point of view, since McWilliams (34) has used intravenously 
500 millions of plain nonsensitized killed typhoid bacilli as the 
initial dose, the safe limit of dosage for sensitized organisms 
would be 1,500 millions; I have used, therefore, 250 to 500 
millions as my dose and, in a very few cases, 1,000 millions. 
I have never exceeded 1,000 millions, even in repeated doses. 
The vein selected for intravenous injection is the median 
basilic, this vessel being commonly prominent, although the 
injection may be given in any other vein provided the site is 
rendered aseptic. The injection should be done under rigid 
asepsis and preferably by the closed method. 
The results of the treatment of thirty cases by intravenous 
injection of sensitized vaccine are shown in Table IV. 
Table IV . — Sensitized typhoid vaccine administered intravenously. 
Classification by results. 
Mild. 
Cases. 
Severe. 
Severe 
and 
toxic. 
Total. 
Days 
before 
treat- 
ment. 
Dura- 
tion of 
treat- 
ment. 
Dura- 
tion 
of dis- 
ease. 
Days. 
Days. 
Aborted 
4 
8 
0 
7 
8.2 
B.l 
13.3 
Benefited 
2 
12 
0 
14 
11.5 
14.4 
25.9 
Relatively unaffected 
0 
0 
3 
3 
8 
25.3 
33.3 
0 
0 
6 
6 
4 
10 
24.1 
1 
In Table IV the cases have been separated into groups 
according to the results ; namely, (a) aborted type, (6) benefited 
type, and (c) relatively unaffected type. 
There were seven aborted cases out of thirty cases treated 
intravenously, with an average duration of treatment of 5.1 
days, in contrast to seven days observed by Gay. (9) McCrae(32) 
in analyzing fifteen hundred cases found 0.1 per cent that re- 
covered by crisis. In my series, I found 23.33 per cent of 
aborted cases. It is interesting to note that the aborted cases 
were observed during the first week, and that they have a direct 
