XIV, 1 Lantin: Treatment of Typhoid Fever 35 
Garbat(8) in his paper quotes the results obtained by some 
investigators who employed sensitized typhoid vaccine intramus- 
cularly, thus: Boinet (1913), 15 cases; Szecsy, 112 cases; and 
Garbat (1911-1912), 17 cases. All of these authors observed 
good results. 
NONSENSITIZED, UNTREATED VACCINE, ADMINISTERED INTRAVENOUSLY 
Following the report by Ichikawa (15) in 1914, on intravenous 
injection of sensitized typhoid vaccine in the treatment of 
typhoid fever, many investigators used his method, but they em- 
ployed a vaccine of the plain bacilli killed by heat. Among 
Ichikawa’s leading followers according to Gay and Chickering(H) 
are Thiroloix and Bardon, Kraus and Mazza, Kraus, Biedl, 
Csernel and Marton, Rhein, Reibmayr, Mazza, Holler, Lowy, 
Luksch and Wilhelm, Paulicek, Dithorn and Schultz, and 
McWilliams. All of these investigators observed beneficial re- 
sults following the use of this form of vaccine. 
There were nine cases in this series treated with nonsen- 
sitized vaccine, administered intravenously. However, the 
patients in this series had been treated at a different time, 
following the treatment of the series that had undergone treat- 
ment by intramuscular injection of sensitized vaccine. The 
clinical grouping of these cases is shown in Table XII. 
Table XII . — Condition of patients before treatment. 
Cases. 
Severe and toxic 1 
Severe and nontoxic 6 
Mild 2 
Total 9 
Total 9 
The results of this treatment are illustrated in Table XIII. 
Table XIII . — Nonsensitized vaccine administered intravenously. 
Cases. 
Days 
before 
treat- 
ment. 
Dura- 
tion of 
treat- 
ment. 
Classification by results. 
Mild. 
Severe 
and 
non- 
toxic. 
Severe 
and 
toxic. 
Total. 
Dura- 
tion of 
disease. 
Days. 
Days. 
Aborted 
2 
3 
0 
5 
11.8 
3.9 
15.1 
0 
3 
0 
3 
16.3 
9.6 
24.9 
0 
Deaths 
1 
1 
Crisis 
1 
3 
20.0 
