38 
The Philippine Journal of Science 
191> 
PEPTONE 
Nolf(36) in February, 1917, published his extended observa- 
tions made in France during the war, on parenteral injection 
of peptone solution in the treatment of infectious diseases in 
general. His experience has shown the efficacy of this treatment 
in typhoid fever, in the consequent ^‘warding olf of intestinal 
haemorrhage from reduced coagulating power of the blood.” He 
employed 10 cubic centimeters of a 5 per cent solution intramus- 
cularly in the gluteal region. Intravenous injection should be 
given slowly and with caution. I was able to apply this form 
of treatment intramuscularly in a very limited number of cases 
that were admitted at the end of the epidemic, when morbidity 
was reduced to the minimum. This series consists of five cases, 
and the relative severity of the infection in each patient is illus- 
trated in Table XV. 
Table XV . — Condition of patients on admissioyi. 
Cases. 
Severe and toxic 0 
Severe and nontoxic 2 
Mild 3 
Total 5 
Following the injection of 10 cubic centimeters of a 5 per cent 
sterile peptone solution every two or three days two mild cases 
aborted in the beginning of the second week of the disease, with 
12.5 days as the average duration of the disease. Three cases 
were benefited; of these, one was mild and two were of the 
severe and nontoxic type, with twenty-two days as the average 
duration of the disease. The total average duration of the 
disease in this group is 17.2 days. There were but two cases of 
defervescence by lysis, and none showed a temperature fall by 
crisis. A summary of the results of the treatment is shown in 
Table XVI. 
Table XVI . — Peptone injection. 
Classification by results. 
Mild. 
Cases. 
Severe 
and 
non* 
toxic. 
Severe 
and 
toxic. 
Total. 
Days 
before 
treat- 
ment. 
Dura- 
tion 
of 
treat- 
ment. 
: 
Dura- 
tion 
of 
dis- 
ease. 
Days. 
Days. 
Aborted 
2 
0 
0 
2 
8.6 
4 
12.5 
Benefited 
1 
2 
0 
3 
12.0 
10 
22.0 
0 
0 
0 
0 
0 
0 
2 
17.2 
