XIV,] Lantin: Treatment of Typhoid Fever 45 
In conclusion, Letulle has stated that this preparation is anti- 
thermic, antitoxic, and without danger to the patient. He bases 
his conclusions on the disappearance of typhoid symptoms such 
as stupor, etc. 
Complications . — The complications observed during the treat- 
ment are shown in Table XXII. 
Table XXII. — Complications before and during treatment. 
Before 
treat- 
ment. 
During- 
treat- 
ment. 
1 
0 
1 
»2 
1 
3 
" One ease developed two days after injection and the other six days after injection. 
We see that there were three cases showing complications 
during the treatment, two of which were of intestinal hsemor- 
rhage and one of lobar pneumonia. The fact that the cases of 
hemorrhage did not appear early — that is, not until after two 
days follovdng the injection — seems to show that the treatment 
did not induce this complication. The proportion of complica- 
tions during the treatment of the series was found to be 20 
per cent. 
Mortality . — Out of fifteen cases in this series there were two 
deaths, a mortality rate of 13.3 per cent. Excluding one hope- 
less case, the mortality rate was 6.6 per cent. Autopsy findings 
of the two cases that were autopsied are shown as follows: 
Autopsies {colloidal gold treatment). 
File No. 2632: A. C. 
Anatomic diagnosis: Lobar pneumonia; typhoid enteritis; parenchy- 
matous degeneration of the viscera. 
File No. 2603: H. G. 
Anatomic diagnosis: Ulcerative enteritis, typhoid, healing; subacute 
splenitis; focal necrosis of the liver; chronic parenchymatous 
nephritis; chronic suppurative bronchitis; cloudy swelling of the liver 
and heart; trichuriasis; chronic pleurisy; emaciation. 
Undoubtedly the two fatalities resulted from complications. 
DISCUSSION 
SPECIFICITY OF THE TREATMENT 
Vaccine therapy has been studied extensively during recent 
years. The practical application of this biologic principle to 
the therapy of typhoid fever has its clue in the fundamental 
