is, 4 Haughwout: Human Coccidiosis 479 
of the parasite. * * * The process is self -limited and repair follows the 
destruction of the parasites. 
I have noted, in connection with the study of some coccidia 
found in the little wall lizards that are common about Manila, 
that infections seem at times to progress rather far, distally, 
along the intestine. This is something I believe other workers 
have noted in the past. It is quite conceivable that a vigorous 
race of coccidia might make a rather long journey along the 
intestine before sporogony intervened, and it is possible that 
effects may be seen in the functioning power of the mucosa long 
after the infection has actually gone. 
TREATMENT 
Treatment for intestinal coccidiosis remains to be worked out. 
In fact, it may be maintained that, in as much as these coccidial 
infections tend toward self-limitation, the matter is of little 
moment. Before adopting that stand as a matter of policy it 
would seem to me to be wise to follow some of the old cases and 
see how they are faring, to give close clinical study toi such new 
cases as may be detected and, moreover, to make a careful study 
of any cases that may occur in children and in people of enfee- 
bled constitution. 
So far, emetine has failed absolutely, and nothing conclusive 
is shown by Noe’s case (12) that he treated with novarsenoben- 
zol and thymol. Miss Porter, ( 13 ) in speaking of one of her 
Johnnesburg cases says (p. 27) : “After the elimination of the 
parasite by appropriate treatment the man recovered.” This 
patient was at first thought to be suffering from amoebic dysen- 
tery, but Isospora was the only protozoan parasite found and Miss 
Porter says (p. 19) : “* * * with its destruction and 
elimination the symptoms' also disappeared.” Unfortunately, 
the writer gives no information as to the nature of the treat- 
ment that was instituted in this case. 
Attempts at treatment of these coccidial infections are likely 
to meet the same obstacles that are encountered with Giardia 
infections. It is barely possible that the intracellular forms may 
be reached with some arsenical preparation. Merozoites enter- 
ing the lumen of the bowel might be reached by a drug such as 
thymol or oil of chenopodium, but the drug would have to be 
exhibited at a time when merozoites were being discharged and 
it might not reach those deep in the intestinal crypts. On 
