102 
virchow’s cellular pathology. 
are multiplied or formed in two other modes, namely; by for- 
mation endogenously and in an amorphous blastema. The 
€hyle and lymph corpuscles, are evidently not formed by pre- 
vious cells. They belong to the domain of free cell develop- 
ment, unless it be contended that even digestion does not break 
down the cells of the food which is digested. We quote again 
from Kolliker, page 49 : “ Free cell formation is exceedingly 
frequent in pathological productions; and the cells in pus, and 
in exudations of all kinds arise in this manner, in fact all patho- 
logical cell formation comes under this head.” These authors 
(Vogel and Kolliker) state the fact of free cell development in 
an amorphous blastema. No theory can stand against an ob- 
served fact— cells are developed from preexistent cellt by fissi? 
parous generation or proliferation as Virchow says, but is this 
the only mode of their generation ? Vogel and Kolliker say that 
it is a fact of observation, that they ’arise in an amorphous 
blastema also ; and when we consider that the cells themselves 
are formed of an organized blastema, the fact of what is called 
free cell formation requires no great stretch of credulity to be 
admitted. Let us say again that this arising of cells in an amor- 
phous blastema does not imply even free, much less spontane- 
ous cell development ; for the invisible germs of cells- — the pro- 
ducts of previous cells may exist in the blastema. The question 
between Virchow and the authors we have cited is this : can 
new cells be developed in a microscopically amorphous blastema, 
and we contend, that so far, facts decide the question in the 
affirmative. Let further investigations finally decide. We 
await them with a decided leaning to the blastema! theory as a 
part of the truth, admitting, of course, the facts of fissiparous 
and endogenous generation as amongst the modes of cell gene - 
sis. Even Virchow admits the endogenous generation in a limk 
ted extent; and that fibrous exudations may become organized 
without the intervention of cells ; so that cells are not everything- 
The theory of Mandl as recorded by Berard, is the prettiest 
of all the cell theories. It is as follows : S 
“ Anterior to any formation there exists a liquid blastema, 
containing corpuscles, which Mr. Mandl calls primitive corpuscles 
.—-(which we noticed above as a blastema and nuclei). 
“ From this condition, the formation of tissues may take two 
different directions, from which will result : 
Missouri Sqtawca’. Cart=m 
George Ehgei#awu ( Papers...^ 
