422 GLANDERS, ANTHRAX PYOCYANEUS 
derivatives only.^ Indol, phenols and similar products of protein 
degradation are not found in cultures of this organism. Gelatin is not 
liquefied and growth is feeble in this medium. 
Frequently cultures on sodium oleate agar slants exhibit a clouding 
of the medium ;''^ the cause of the clouding is not known. 
Pathogenesis.— Escherich^ and Salge"* have described acute diarrheas 
in yoimg children, characterized bacteriologically by large numbers 
of Gram-positi\'e bacilli in the feces which are strongly acid in reac- 
tion; Escherich applied the name "Blaue Bazillose" to this type of 
intestinal disturbance, because of the great preponderance of Gram- 
positive bacilli in Gram-stained preparations prepared directly from 
the feces. Subsequent investigations have shown that the "blue 
bacilli" were in all probability B. acidophilus, and it has been shown 
that a condition apparently identical with that described by Salge may 
develop in young children fed with too much maltose or malz suppe.^ 
Under certain conditions it may be desirable to introduce acidophilic 
bacteria into the intestinal tract for therapeutic purposes. Cultures 
that are known to acclimatize in the alimentary canal must be used 
for this purpose.*^ The organism may be introduced through a 
duodenal tube. 
Bacillus Acidophil-aerogenes.— Torrey and Rahe^ have described a 
member of the aciduric group of bacteria which produces acid and gas 
in glucose, lactose, saccharose and maltose; mannitol was not fer- 
mented. The morpkology of the organism, the types of colonies 
produced on glucose agar, and its staining reactions resemble those of 
B. acidophilus. The production of gas in the sugar mentioned and 
the relatively feeble growth in milk are its distinguishing cultural 
characteristics. 
Sera of animals immunized to B. acidophil-aerogenes failed to 
agglutinate B. acidophilus, and lice versa, indicating that the two 
organisms are quite distinct entities. 
■ Kendall and Haner: Jour. Infec. Dis., 1924, 35, 89. 
2 Kendall and Rahe: Loc. cit. 
3 Jahrb. f. Kinderheilk., 1900, 52, 1. 
■• Die akute Diinndarmkatarrh des Sauglings, Leipzig, 1906. 
6 Kendall: Boston Med. and Surg. Jour., 1910, 163, 322. 
6 Rotch and Kendall: Am. Jour. Dis. Child., 1911, 2, 30. Cheplin and Rettger: 
Proc. See. Exp. Biol, and Med., 1920, 17, 192. 
■ Jour. Infec. Dis., 1915, 17, 437. 
