Observations oa the Histology of Cancer. 
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in figs. 3 and 4. In the latter the transition from the red-staining 
cell-protoplasm to the cyanophile granules is shown, also the for- 
mation of small fragments side by side with larger ones. 
Fig. 5 illustrates a most important and in squamous epithelioma 
a common condition, that is the presence of both reticular non- 
nucleated corpuscles certainly not leucocytes and of nucleated leuco- 
cytiform corpuscles enclosed by the remains of one of the red staining 
free-bodies. A similar condition from a hmmatoxylin stained pre- 
paration I have described and figured elsewhere 1 ) and L. Pfeif- 
fer 2 ) has also figured a similar condition. From the study of a 
large number of cancers of various kinds I have come to the con- 
clusion that the leucocytiform corpuscles like the non-nucleated bodies 
are daughter-cells of the large red-staining bodies and not leucocytes. 
For, besides the occurrence of such corpuscles side by side with the 
reticulate bodies within the same capsule (remains of the large 
red-staining bodies) there occur in support of the idea such bodies 
as are shown in fig. 6 as well as other appearances to be mentioned 
later. 
Fig. 6 represents two corpuscles lying side by side in a Collec- 
tion of similar free bodies. 
The lower of the two shows four of the leucocytiform bodies at 
the periphery of one of the red-staining bodies. Are they phagocytes ? 
Two circumstances led me to conclude in the negative. First although 
the tissue has been hardened in spirit and Müller and not fixed by an 
instantaneous process, there is no indication of Separation between 
the corpuscles and remains of the original red-staining body but on 
the contrary there is distinct evidence of organic continuity between 
the corpuscles and the remains of the red-staining body. In the 
second place the upper of the two elements in fig. 6 shows distinctly 
the formation of daughter-cells within one of the red-staining bodies. 
The nuclei of these corpuscles their form and arrangement is not 
compatible with their being leucocytes and is only compatible with 
their being the result of irregulär mitotic processes similar to those 
shown in figs. 1 and 2. 
The most rudimentary element which results from the subdivision 
of the red-staining bodies is a small granulär sphere 3 — 4 /.i in 
diameter such as are shown in fig. 7. Mixed with these bodies are 
sometimes irregulär cyanophile filaments and sometimes leucocytiform 
corpuscles, as shown in fig. 7. The reaction of the granules to 
ßiondi is red, the importance of this reaction is however not great 
because to acid hsematoxylin their reaction is constantly blue and 
when treated with iodine green by itself they stain intensely green. 
I regard these granulär spheres as homologous with bodies I have 
described in other cancers and with stages in the life-history of Coccid. 
Oviform, and of the Psorosperms of ureter. They are certainly not 
leucocytes nor have they ever been leucocytes which have undergone 
1) Jackson Clarke, Morbid growths and sporozoa. 1893. fig. 9. 
2) L. Pfeiffer, Untersuchungen über den Krebs. 1893. 
