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degeneration. The last portiou of dead leucocytes to remain is the 
nucleus which is absent in the bodies in question. 
Another phase of subdivision of the free red-staining bodies is 
shown in fig. 8. This phase I take to be identical with that delineated 
by L. Wickham and which I have described elsewhere 1 ). The 
result of the subdivision leads to the formation of reticular bodies 
oval or round which stain deeply with nuclear dyes and some show 
a formation of a nucleus (as shown in fig. 9) apparently by conden- 
sation of chromatic filaments. 
In mauy of the capsules both red, green, and nucleated bodies 
are fouud side by side, see fig. 9. This is only an example of 
the uncertainty of the reaction of the Biondi reagent; for as I 
have stated above both the reticular and the granulär bodies stain 
well with acid hsematoxylin. The Biondi reagent has another serious 
drawback in that it frequently fades rapidly. Thus all results ob- 
tained by the use of this stain should be checked by the use of more 
reliable reagents such as haematoxylin and eosin. The great value 
of the Biondi reagent is in its giving good differential pictures for 
demonstration. 
Perhaps the most convincing of all the appearences obtained in 
the study of squamous epithelioma are such as can be isolated by 
teasing and have beeu described by L. Pfeiffer, Wickham and 
myself. To select two of these I would mention round doubly re- 
tracting capsules (see L. Pfeiffer, Protozoen als Krankheitserreger) 
filled with small round non-nucleated bodies, and besides these the 
irregulär branched sometimes longitudinally striated bodies well 
described by Korotneff and Kurl off (I showed drawings of the 
same bodies to the Pathological Society in 1892), may be isolated 
and shown to be breaking up into the same round granulär bodies. 
Fig. 10 represents a body of this kind which I have demonstrated 
to the above-named society 2 ). The body was isolated from a teasing 
made from a piece of tissue stained in bulk with borax-carmine. 
The granulär bodies are about equal in size and none of them 
appear to have definite nuclei. Thus it will be seen that while I 
agree with Korotneff that the large irregulär bodies are parasites, 
the phases of sporing I have met with differ from those described 
by this distinguished biologist. As I found in the so-called psoro- 
sperms of the human ureter 3 ) so in the squamous epithelioma and other 
cancers the elementary swarm-spore in a granulär corpuscle which 
is frequently devoid of a nucleus. These granulär spores mixed with 
leucocytes form the contents of the broken-down epithelial pearls of 
squamous epithelioma. 
I would here explain that I employ the term spore in a wide 
sense, to include both sporogonia and spores proper. There is at 
present no safe ground for absolute destinction of these structures. 
The study of secondary growths in lymphatic glands gives farther 
1) Abstract of paper. (Brit. Med. Journ. 1892. Dec. 24.) 
2) Abstract. (Brit. Med. Journ. 1894. May 19.) 
3) Jackson Clarke, Path. Soc. Trans. 1892. 
