Observations on the Histology of Cancer. 
285 
Support to the view that many cells in cancerous growths closely 
simulate leucocytes but are seen to result from the subdivision of 
so-called cancer-cells. In glands infected from cancerous breasts 
the form of subdivision of the parasites usually resembles that 
shown in the upper of the two elements in fig. 6 but in the case of 
glands iDfected from epidermoidal cancer the mode of subdivision 
more commonly resembles that shown in fig. 5 and the study of the 
advancing edge of the growth in such cells strongly supports the 
view of L. Pfeiffer, namely that the sporozoa of cancer are poly- 
phagous in the same sense as myxosporidia, sarcosporidia etc. and 
that in come cases the parasites invade and destroy tissues indepen- 
dently of epithelial cells. And though it has been shown that epi- 
thelial emboli may easily be detached from cancerous growths the 
contemplation of the earliest foci of secondary growths in omentum 
shows that the foci are composed of small round cells which have 
none of the distinctive characters of epithelium. I conclusion I would 
express the opinion that it is no argument to dispose of the bodies 
I have described in this paper by terming them pseudo-coccidia 
as has been done by Metschnikoff. 
If the parasites of cancer were known to be coccidia this course 
would be open, but there is every reason to believe that the sporo- 
zoa of cancer ave not coccidia in the biological sense of the word. 
Düring the last three years I have frequently kept slices of cancer 
in moist chambers for different periods of time and in one instance 
only have I met with a body resembling an encapsuled coccidium 
oviforme. This was in an epidermoidal cancer which had been in a 
Petri dish for six weeks. This coccidiumlike body showed no forma- 
tion of lasting spores. 
1894, July 3. 
Description of figures. 
Fig. 1. Free parasite showing mitotic activity. 
Fig. 2. Free parasite showing a form of nuclear activity with the presence of 
cyanophile and erythrophile granules. 
Fig. 3. Free parasite showing cyanophile granules arranged in four masses. 
Fig. 4. A body similar to “3” showing erythrophile to cyanophile particles and 
the formation of granulär bodies. 
Fig. 5. A free parasite subdividing into leucocytiform and granulär bodies, the 
latter are composed throughout of a mixture of red and blue granules but without a 
nucleus. 
Fig. 6. Two free parasites, the upper one dividing into round daughter-cells, the 
lower one dividing into leucocytiform cells and simulating phagocytosis. 
Fig. 7. A free parasite divided ints granulär “spores” most of which are stained red. 
Fig. 8. A similar parasite with reticular spores stained green. 
Fig. 9. A parasite similar to that shown in fig. 8 particles of the original mother- 
parasite remain among the green “spores”. 
Fig. 10. An irregulär parasite subdividing into granulär spores, isolated by teasing 
of a specimen stained with borax- carmine. 
All the figures were drawn with Zeiss’s 1 / li in. oil-imm. Zeiss oc. 3 and all 
except that shown in fig. 10 were stained with B i o n d i. 
