810 
J. Jackson Clarke, 
This observation remained isolated until in January 1892 I read \ 
before the Pathological Society a paper 1 ) in which I described *t 
sporozoa in certain sarcomata. Some of the illustrations I exhibited .« 
at that time are reproduced elsewhere 2 ). About the same time I •< 
published 3 ) a brief note expressing the same view. 
In the course of this paper I said speaking of a sarcoma of 
the testis 3 ). “In the intervascular areas were immense numbers of • 
psorosperms in the Condensed highly refracting stage and the same I 
processes of reticulation and spore-formation I had described in . 
cancers could be traced in all the sarcomata I had examined”. 
Ribbert in a recent article 4 ) referring to my work on sarcoma » 
States “Verfasser fand ähnliche Einschlüsse auch in Sarkomen, nachdem i* 
vor ihm bereits Steinhaus 5 ) sie in den Kernen dieser Geschwülste • 
beschrieben hatte, deren Bedeutung er indes nicht festzustellen ver- f 
mochte, und Pawlowsky ein Protoplasma der Sarkomazellen ge- 
sehen hatte, das er als Protozoen ansprach”. 
I have unfortunately not yet been able to see the paper of 
Steinhaus but according to Ribbert the author restricts his 
description to intranuclear bodies and comes to no decided conclusion 
as to their nature. 
Pa wlo vsky’s 6 ) article is fully illustrated by drawings which 
are certainly more carefully done than those I have hitherto been 
able to publish but as certainly refer to the same structures which 
I had previously described e. g. in a round-celled sarcoma of the 
testis. 
Lindsay Steven and Brown 7 8 ) describe and delineate in 
sarcoma cell-inclusions which they regard as homologous with the 1 
cell-inclusions described by Soudakewitch as sporozoa in cancer. 
In order to present my views fully it would be necessary to 
indicate the relation of the bodies I regard as parasites to elements j 
described by the older writers. Such a task I have commenced 
elsewhere s ) but it is not yet completed so that it will be simpler 
to indicate the relation borne by the bodies described by various 
authors as sporozoa in cancer to those to which I now ask attention. 
One of the commonest of these cell-inclusions is a round or oval 
dense homogeneous body w'hich lies in a space close to the nucleus i 
and is usually surrounded by a capsule which is however sometimes 
wanting. Such a body within an epithelial cell of a cancer of the 
breast is represeuted in fig. 1. The cell-inclusion in a section stained 
with Biondi is of a reddish-brown colour. Seen alone such a 
structure cannot Claim any especial attention although quite similar 
non-nucleated bodies are met with as unquestioned intracellular 
1) Abstracted Brit. med. Journ. 1892. Jan. 21. 
2) Jackson Clarke, “Morbid Growths and Sporozoa”. 1893. figs. 71 and 73. 
3) I b i d. , Brit. med. Journ. 1892. Jan. 21. 
4) Ribbert, Deutsche med. Wochenschr. 1894. April 12. p. 343. 
5) Steinhaus, Centralbl. f. pathol Anat. 1893. p. 593. 
6) Pawlovsky, Virchow’s Archiv. 1893. Sept. 1. 
7) Lindsay Steven and Brown, Journal of Pathol. 1893. Oct. 
8) Abstract of paper Brit. med. Journ. 1894. May 19. 
