CASE OF ACUTE GLANDERS OF SPONTANEOUS ORIGIN. 25 
altogether, now, assuming the form more of acute glanders 
than anything else ; and yet, as there was no purulent 
secretion from the nasal fossae, I still suspended my judg- 
ment. M. Lecoq, (veterinarian,) to whom I showed the case, 
w 7 as, in the absence of nasal discharge and glandular en- 
largement, unwilling to pronounce upon it. Abscesses and 
pustules continue to multiply ; the face becomes swmllen and 
erysipelatous, and phlyctenae appear upon it; the pulse rises 
to 130; the tongue looks as though it had been roasted, and 
little black incrustations are seen inside the nose, but no 
discharge appears. Nevertheless, if the case be not one of 
glanders, w 7 e know of nothing like it in our nosology. Four- 
teen days after admission, Adelaide James expired under an 
attack of diarrhoea and fresh eruptions of phlyctenae. 
Post-mortem . — Six or seven bullae upon the limbs; tw r o 
gangrenous phlyctenae, and twenty-nine opaque pustules, 
resembling those of variola, w T ere found in various parts, 
twenty-tw 7 o of which are in a state of abscess, and two 
gangrenous ; some being subcutaneous, others deep-seated 
among the muscles, and others intra-articular. The nasal 
fossae exhibit thickening, softening, and reddening of the 
lining membrane, with infiltration and readiness of detach- 
ment from the bone, and in some place erosions infiltrated 
with pus (an essential character of glanders). The turbi- 
nated protuberances had turned black, and w 7 ere filled w ith 
sanguinolent and purulent mucosities, giving evidence of 
speedy discharge from the nose. The lungs w 7 ere infiltrated 
with black blood. The genital organs exhibited no syphilitic 
trace, nor were the lymphatic glands visibly engorged. 
M. Lecoq, importuned by me to give his opinion of the 
case, said that if such symptoms had presented themselves 
in a horse, he should have called it acute glanders. Still, one 
proof w 7 as wanting, and that was inoculation. This w 7 as 
resorted to. Pus taken during life from one of the abscesses 
w 7 as imparted by inoculation to a horse in low condition, but 
in good health, and in ten days after this animal succumbed 
under all the symptoms of acute glanders. 
In reviewing the above case, M. Teissier cannot regard it 
as having any relationship to irregular smallpox, malignant 
pustule, phlebitis, angeioleucitis, or even secondary syphilis ; 
neither does he think there exists any grounds for pro- 
nouncing the disease under which Adelaide James laboured 
to be a morbid individuality, hitherto undescribed, having 
some relations to glanders, but yet not identical with that 
affection. There is certainly a difficulty in conceiving such 
a disease (supposing it to be glanders) arising spontaneously 
xxvi. 4 
