A NEW MEMOIR ON PLEURO -PNEUMONIA. 91 
Nevertheless, the virus or poison ordinarily produces a local 
action more or less impressive upon the tissues with which it 
comes in immediate contact. Since we possess no other 
indication of the virus having produced its action, save the 
local morbid manifestation, it becomes advisable to reinoculate 
every beast on whojn the first inoculation has been without 
effect ; and this is absolutely the case with vaccine in man. 
I ought, however to remark that we may often observe an in- 
dicative sign of the absorption of the virus, although no lesion 
may be visible at the point of the tail, in fulness and swelling 
and hardness of the sacral glands at the insertion of the tail. 
“ In my last letter I had the honour of informing you that 
I have been seeking, experimentally, for a more convenient 
place for inoculation than the point of the tail. Now, how- 
ever, I no longer think about it, and am rather anxious to 
retract what I said about inoculation in the dewlap, ( fanon ,) 
an error I was led into by M. Mavis, Y. S., who too pre- 
maturely announced his success in this attempt. 
“ Many persons think that inoculation for peripneumonia 
is more conveniently practised in the dewlap than in the tail ; 
but such persons are solely guided by theoretic views and 
not by experience. For instance, M. Mavis, V. S. of the 
Government at Hasselt, desirous of modifying my method 
of procedure, inoculated about thirty beasts in the dewlap, 
and this is the result. At the commencement of August 
sixteen beasts, were inoculated in the dewlap, belonging to 
M. Claes : twelve of them fell victims to the consequences of 
the operations. At M. Mavis’, brewer, at Hasselt, two cows 
were inoculated in the dewlap : both died. At M. Ant. 
Vinkerbosch’s two oxen were inoculated in the dewlap, and 
they likewise both shared the same fate about fifteen days 
subsequent to the operation. Thus, through bad inoculation, 
have many beasts been killed outright. 
“ I have seen two cases wherein pleuro-pneumonia coincided 
with the local accidents of inoculation. 
“ On the 25th of August a beast belonging to M. Borreman, 
distiller at Hasselt, that had been inoculated on the 5th of 
August, having the tail much enlarged and the right limb very 
much swollen, presenting all the local phenomena of inocula- 
tion in their greatest intensity, died. In the autopsy I found 
a nucleus of morbid hepatisation. Did this come on imme- 
diately after inoculation, or did such lesions exist previously ? 
I have frequently know n, after the virus has been introduced 
into the tail, tumours arise characteristic of inoculation in 
different parts of the body, wdthout the part where the virus 
was introduced presenting the slightest damp in its tissues. 
