394 COMMUNICABILITY OF ASIATIC CHOLERA 
fluid part of one ounce of cholera-blood, taken from a patient 
who had been seized early the same morning, and died 
twenty-four hours after. No alteration in the faeces, nor any 
other symptoms followed during the next twenty-one days. 
Magendie injected various quantities of cholera-blood into dogs 
without specific effects; but he relates* that his prosector, M. 
Loir, having removed eight ounces of blood from a living 
dog, replaced it by the same quantity of human cholera-blood 
defibrinated. The dog died in eight hours, with symptoms 
resembling cholera ; i. e., both vomiting and purging, but of 
what nature is not described. After death, the veins con- 
tained very black blood, and the intestines reminded him, in 
appearance, of those of a cholera body. 
Our own experiments with fresh cholera-blood were six in 
number. The blood was, in all cases, conveyed in stoppered 
bottles, slightly diluted with distilled water, defibrinated, and 
injected within twenty to thirty minutes of its abstraction 
from the body, into the jugular vein of the animal employed. 
Experiments 1 and 2. — Blood from a patient, late in the 
algide stage ; died soon afterwards. Nearly 3 drachms into 
a large rabbit : animal drooped for a few hours only ; then 
recovered itself. 6 drachms into a small dog: prostration 
for rest of day ; bowels slightly relaxed ; faeces opaque white, 
covered with greenish yellow mucus ; no appetite until next 
morning, when dog was hungry. Diarrhoea through the day, 
yellowish. On second day, faeces quite natural. 
Exp. 3 and 4. — Blood from a patient only 6 hours after 
seizure ; collapse slight ; death 23 hours after. 3 drachms 
into a cat : animal became quiet and suspicious ; faeces at 
first hard, afterwards relaxed, blackish, and mixed with 
mucus. Next day, well. 4 drachms into a large dog : no 
symptoms but those of temporary weakness and refusal to 
eat. 
Exp. 5 and 6. — Blood from patient 10 hours after attack, 
15 before death. 3 drachms into a kitten six months old: 
only symptom, loss of appetite and prostration for some 
hours. 4 drachms into a dog : the same debility, indifference 
to food, and suspicious aspect, continuing for the rest of the 
day; faeces twice passed; very soft in the first night, the 
second more so than the first; recovery complete on the 
second day. 
Two counter-experiments may be added to these, in which 
4 and 6 drachms of fresh human defibrinated blood, from a 
case of injury to the chest, and from one of pleurisy, were in- 
jected into the veins of two dogs, without other effects than 
* Le^ns, &c., pp. 126, 138, 158. 
