PLEURO-PNEUMONIA IN CATTLE. 
413 
I have made inoculations with the saliva and other liquids, 
but I do not approve of them ; I shall speak of them further 
on. I have inoculated in other parts than the tip of the tail; 
in the detail of my observations, the inconveniences of these 
different modes of proceeding will be stated. 
After an inoculation with the virulent liquid, which usually 
goes from twelve to thirty days, the phenomena of the 
inoculation manifest themselves, and have at times lasted in 
some animals as long as tw r o or three months. The disease 
which is inoculated is not a purely local one : the autopsies 
of the animals that died in consequence of the inoculation, 
have proved this to me ; and then the uneasiness which the 
animal experiences often some days after the inoculation, is 
not in proportion to the slight local injury. When the first 
phenomena manifest themselves, the animal suffers, it is less 
lively, eats less ; when the place where the inoculation was 
made is touched, the part is usually sensitive, then it sw r ells, 
becomes inflamed, and greatly indurated ; this inflammatory 
hardness of the morbid tissues sometimes extends to a 
distance, and when the inoculation has been made in an 
ill-selected situation, death may ensue. In the swollen part 
there is made an excessively abundant deposit of exsudated 
matter, absolutely as in the lungs of diseased animals. This 
swelling often dissipates itself, often also mortification seizes 
it, and shreds of the skin are sacrificed, sometimes even the 
whole tip of the tail. There are still in our stables at least 
ten oxen which have lost the tips of their tails in this way. 
When all the phenomena of the inoculation succeed each 
other regularly, the animal suffers but little uneasiness, and 
soon after it is more cheerful than before, it has better 
health, and fattens more easily, as I have had the honour to 
s a y. 
I have examined various pathologic specimens (see Fig. 1, 
p. 7), with the object of studying and elucidating the question 
of inoculation : my investigations have been principally 
directed to diseased lungs, and to a kind of tubercle hitherto 
overlooked, but which I have, nevertheless, constantly met 
with upon opening the dead bodies of animals that died from 
pleuro-pneumonia. These tubercles, scattered throughout 
the intestines, but principally in the lesser one, are of a size 
varying from the head of a pin to that of a large pea, of a 
yellowish or greenish colour ; they are seated in the sub- 
mucous cellular tissue, and partly in the thickness of the 
mucous membrane of the intestine. They do not appear to 
have any tie of origin with the glands of Peyer or of 
Brunner. Are they hypertrophied follicles? Nothing ap- 
