454 INOCULATION FOR PLEURO-PNEUMONIA IN CATTLE. 
consequently requires a reply from us. Reserving, however, 
for the present any further allusion to this matter, we pass to 
the subject immediately requiring attention. 
In the first place, we shall give a brief history of the pro- 
gress and rate of mortality of Pleuro-pneumonia in the herd 
of cattle among which our experiments have been instituted ; 
a step rendered the more necessary in consequence of the 
effects which have followed inoculation. Any means which 
are correctly used to effect a proper solution of the question 
of inoculation cannot fail to be of interest to the agriculturists 
and cattle proprietors of this country, and the more so because 
here, as elsewhere, no efficient method of cure of Pleuro- 
pneumonia has been discovered. Hence we may remark, that 
the Royal Agricultural Society is under peculiar obligations 
to those public-spirited individuals who have shown their 
willingness to give up their cattle for legitimate experiments. 
It is deeply to be regretted that, while all persons are so 
ready to reap the benefit, so few T can be found to incur the 
risk of a scientific investigation. It is right, therefore, to call 
attention to the fact named by Mr. Pusey, in a note appended 
to the former Report, “ that it was with the kind assistance 
of Mr. E. Denison, M.P., and through the liberality of Mr. 
Paget, of Ruddington Grange, near Nottingham, that the 
Society was enabled to make arrangements for testing the 
efficacy of inoculation.” 
On our first visit to Ruddington, Mr. Paget kindly placed 
at our disposal any number of animals we might select for 
the experiment of inoculation ; and this notwithstanding he 
’was in full possession of our opinion as to the serious ill con- 
sequences which might attend the operation, as well as our 
doubts of its ultimately proving of any value as a prophylac- 
tic. From the history given, it appears that Pleuro-pneumo- 
nia, which had prevailed more or less in the neighbourhood 
of Nottingham since 1843, first showed itself in Mr. Paget’s 
herd in August, 1849. The attack was very virulent, and 
between this time and Christmas of the following year it car- 
ried off no less than seventy animals. In 1851 thirty fell a 
sacrifice to the disease, and from January, 1852, to the end 
of November, when the experiments were commenced, thirty- 
two more animals were destroyed by it. We have thus a 
total loss of 132 animals from August, 1849* to November, 
1852, inclusive; a period of little more than 3| years. From 
the changing state of the herd, the ratio of deaths to the 
number kept cannot now be ascertained, but it will be seen 
that the losses may be described as being ruinous in amount. 
Mr. Paget milks upon the average sixty cows for the supply 
